{"id":"W1983873281","doi":"10.1177/1087057112470563","title":"Novel Methodology to Identify TRPV1 Antagonists Independent of Capsaicin Activation","year":2012,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"TRPV1; Capsaicin; Agonist; Neuroscience; Transient receptor potential channel; Drug discovery; Pharmacology; Chemistry; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007661317,0.0008667186,0.0007735817,0.0008957774,0.0003517111,0.0005599022,0.00079359,0.000611139,0.002493497],"category_scores_gemma":[0.0007511274,0.0004395095,0.0005773379,0.000483592,0.0004116642,0.0006092298,0.0005133614,0.00144378,0.001217739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003841315,"about_ca_system_score_gemma":0.0007117009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431457,"about_ca_topic_score_gemma":0.0008421101,"domain_scores_codex":[0.9992594,0.0001566969,0.00005640976,0.0001815128,0.0002152601,0.0001306996],"domain_scores_gemma":[0.9996903,0.0001016831,0.0000522727,0.00005400427,0.00006774649,0.00003406728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007355951,0.0001194616,0.00005724097,0.0001371386,0.00001801284,0.00007196832,0.0000308251,0.0003125023,0.9870774,0.0008558607,0.0002324451,0.01101356],"study_design_scores_gemma":[0.000112571,0.001470122,0.0005355513,0.00001635842,0.00003779517,0.0004757023,0.0000214331,0.00305669,0.9834617,0.0004331269,0.01035141,0.00002756155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2608468,0.007127844,0.7092929,0.00105301,0.000355297,0.003842632,0.001315745,0.001809783,0.0143559],"genre_scores_gemma":[0.6168784,0.00674259,0.3570735,0.001169905,0.0001601611,0.002910221,0.002030496,0.0002445315,0.01279018],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002493497,"threshold_uncertainty_score":0.00834161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1395408379141042,"score_gpt":0.3825972041633847,"score_spread":0.2430563662492805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}