{"id":"W1983879753","doi":"10.1016/j.jns.2006.11.021","title":"Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators","year":2007,"lang":"en","type":"review","venue":"Journal of the Neurological Sciences","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Matrix metalloproteinase; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Downregulation and upregulation; Minocycline; Medicine; Immunology; Encephalomyelitis; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001153439,0.0001409814,0.0005630954,0.0001156721,0.00004277013,0.00001135,0.0004515146,0.0001773215,0.000005575165],"category_scores_gemma":[0.0005288324,0.0000649848,0.0004780039,0.0003002582,0.0002612585,0.000009326377,0.0001546831,0.0001855053,1.236115e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008659799,"about_ca_system_score_gemma":0.0001347275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002053751,"about_ca_topic_score_gemma":0.000002413439,"domain_scores_codex":[0.9986142,0.0002227798,0.0006185354,0.0001570633,0.000246705,0.0001407484],"domain_scores_gemma":[0.9986748,0.00006979051,0.00102705,0.0001284849,0.00006133872,0.00003857831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003735271,0.000499742,0.005889796,0.00125519,0.0002489293,0.00001380457,0.00002239653,0.0002955728,0.5487953,0.0001385859,0.00007000398,0.4423971],"study_design_scores_gemma":[0.005123404,0.07657006,0.06420002,0.01936065,0.002206833,0.002050137,0.00009946613,0.0004074066,0.7153203,0.006874167,0.1052851,0.00250235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5028387,0.4969157,0.00001340064,0.000007658998,0.00006471961,0.0001472942,0.000005449734,4.318385e-7,0.000006663933],"genre_scores_gemma":[0.4818363,0.5179263,0.0001744334,0.000008785035,0.00004553294,0.000001585041,5.663032e-7,0.000003486447,0.000002992041],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.4398948,"threshold_uncertainty_score":0.2650003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07726765518114447,"score_gpt":0.3352162647541727,"score_spread":0.2579486095730282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}