{"id":"W1983890005","doi":"10.1038/ni1298","title":"Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope","year":2006,"lang":"en","type":"article","venue":"Nature Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"CTL*; Epitope; Virus; Virology; Biology; Cytotoxic T cell; Viral replication; Population; Negative selection; Immunology; Genetics; Antigen; Gene; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0005849393,0.0004942906,0.0007421474,0.0005138111,0.0005996607,0.00004876906,0.0006714713,0.001412244,0.0005507188],"category_scores_gemma":[0.0001165773,0.0004280075,0.0001772349,0.0004697629,0.0004623701,0.000248602,0.0001857316,0.002376083,0.001208772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003865776,"about_ca_system_score_gemma":0.0001687881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004700542,"about_ca_topic_score_gemma":0.001767941,"domain_scores_codex":[0.9961585,0.0009278224,0.0006385804,0.0008075576,0.0000970855,0.001370412],"domain_scores_gemma":[0.9984427,0.0003966698,0.0002778308,0.0006439493,0.0002044122,0.00003440061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000751808,0.0008837447,0.006998331,0.00001416725,0.0001800345,0.0000636922,0.0007371758,0.000005832571,0.9845551,0.001745129,0.0004058629,0.003659138],"study_design_scores_gemma":[0.007162318,0.002373545,0.1108213,0.00005546785,0.00004775361,0.0001122761,0.0005260601,0.000002177129,0.8566145,0.0003075402,0.0214161,0.000560984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9321882,0.06082573,0.00001015117,0.00009513625,0.0008562503,0.0008332627,0.0001080469,0.0001462743,0.004936929],"genre_scores_gemma":[0.9966459,0.0003927815,0.0000742968,0.00006950383,0.00005737695,0.000156698,0.001162045,0.00005326741,0.001388151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1279406,"threshold_uncertainty_score":0.9999255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007142315118996358,"score_gpt":0.2968641569480402,"score_spread":0.2897218418290438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}