{"id":"W1983890005","doi":"10.1038/ni1298","title":"Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope","year":2006,"lang":"en","type":"article","venue":"Nature Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"CTL*; Epitope; Virus; Virology; Biology; Cytotoxic T cell; Viral replication; Population; Negative selection; Immunology; Genetics; Antigen; Gene; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002820744,0.0002099179,0.0002855884,0.0002215355,0.0006682226,0.0006921857,0.0004255494,0.0004565637,0.002300522],"category_scores_gemma":[0.0006575311,0.0002619989,0.0001596689,0.0001537476,0.0004207876,0.0005297748,0.0004553094,0.0007767277,0.0004637248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003258693,"about_ca_system_score_gemma":0.0001863396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003532341,"about_ca_topic_score_gemma":0.0007413384,"domain_scores_codex":[0.999719,0.00005726084,0.00001714537,0.00003287417,0.00006225073,0.0001115586],"domain_scores_gemma":[0.9994185,0.0003054113,0.00005636932,0.00004170043,0.00004344582,0.0001345757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004671848,0.00003698064,0.0003473577,0.00001815812,0.000009234322,0.0001584365,0.00004065288,0.0004027834,0.996787,0.0005126671,0.00005109464,0.001168465],"study_design_scores_gemma":[0.00009708091,0.0005707729,0.006130681,0.00001015809,0.00004529815,0.0009662505,0.0002995726,0.006743007,0.9835165,0.0006349317,0.0009569991,0.00002884586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992282,0.00009500772,0.0002127083,0.00001719973,0.000007376531,0.000002054944,0.000007651719,0.000004742686,0.0004250149],"genre_scores_gemma":[0.9995546,0.00003882805,0.0001951378,0.00002044879,0.000003884641,0.000001742855,0.00001219407,0.000006950288,0.0001662527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300522,"threshold_uncertainty_score":0.007696033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007142315118996358,"score_gpt":0.2968641569480402,"score_spread":0.2897218418290438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}