{"id":"W1983914707","doi":"10.1016/j.febslet.2012.09.017","title":"Engineering a naturally inactive isoform of type III antifreeze protein into one that can stop the growth of ice","year":2012,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research","keywords":"Antifreeze protein; Gene isoform; Antifreeze; Chemistry; Ice crystals; Biophysics; Biochemistry; Crystallography; Biology; Physics; Gene; Optics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738607,0.0003082787,0.0002152275,0.000122789,0.0001018312,0.0002501023,0.0003637886,0.0002994673,0.00094816],"category_scores_gemma":[0.0001698062,0.0001154015,0.0002585686,0.0001204873,0.0002830234,0.0001637452,0.0001841478,0.0006224921,0.0003473284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745565,"about_ca_system_score_gemma":0.0001797554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003209503,"about_ca_topic_score_gemma":0.0004428035,"domain_scores_codex":[0.9999081,0.00001206866,0.00001306136,0.00002301765,0.00002620023,0.00001747979],"domain_scores_gemma":[0.9998322,0.00003685648,0.00004742505,0.0000251559,0.00002225397,0.00003602846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005286616,0.00002648383,0.0001393706,0.00001428369,0.000004921912,0.00005992989,0.0000113965,0.00006647649,0.9987637,0.0001131194,0.00002918132,0.0007183677],"study_design_scores_gemma":[0.0000243398,0.0002007683,0.002059091,0.000004250423,0.00001705439,0.0004768408,0.00002875153,0.001467423,0.9914179,0.0000765502,0.004220187,0.000006880024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871897,0.0001837291,0.01085666,0.0001428127,0.00007400649,0.00005973839,0.0003097516,0.0001079377,0.001075568],"genre_scores_gemma":[0.9855232,0.0001860341,0.0107203,0.0000823517,0.00001382599,0.00003494421,0.0005752903,0.00009636708,0.002767618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00094816,"threshold_uncertainty_score":0.003171921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250153205359891,"score_gpt":0.1910091868963272,"score_spread":0.1785076548427283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}