{"id":"W1983914724","doi":"10.1021/bi060017f","title":"Roles for Arg426 and Trp111 in the Modulation of NADH Oxidase Activity of the Catalase-peroxidase KatG from <i>Burkholderia pseudomallei </i>Inferred from pH-Induced Structural Changes<sup>,</sup>","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chemistry; Peroxidase; Catalase; Enzyme; Oxidase test; Oxygen; Ferric; Electron paramagnetic resonance; Oxidoreductase; Stereochemistry; Crystallography; Biochemistry; Inorganic chemistry; Nuclear magnetic resonance; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045704,0.0001831161,0.0002331579,0.0000203335,0.00009453692,0.00002025635,0.0002382485,0.0001641761,0.000009885007],"category_scores_gemma":[0.00009719498,0.0001268846,0.000141509,0.00009936995,0.0001146164,0.000008690228,0.0000969828,0.0000915094,2.03999e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000169428,"about_ca_system_score_gemma":0.00003347673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002397087,"about_ca_topic_score_gemma":0.0004288066,"domain_scores_codex":[0.9990248,0.00005368401,0.0002521969,0.0003487179,0.0001573718,0.0001632475],"domain_scores_gemma":[0.9991276,0.00005484714,0.0002362004,0.0004667705,0.00008816009,0.00002648183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001858611,0.00005831205,0.003216127,0.00002765157,0.00007704402,4.862826e-7,0.0001095277,0.00006468652,0.9952811,0.000002812463,0.0002305968,0.0007458047],"study_design_scores_gemma":[0.0007432739,0.00004135368,0.02674823,0.00004174476,0.00005759257,0.000001605737,0.000417193,0.001890554,0.9697511,0.00008894632,0.00008393308,0.0001344724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982638,0.0004897677,0.0001108095,0.0003066616,0.0000373547,0.0002531192,0.0005055339,0.000004164967,0.00002881255],"genre_scores_gemma":[0.9990218,0.00002655383,0.0001582042,0.00006092451,0.0002457044,0.00005829933,0.0003804742,0.0000115247,0.00003652105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02552999,"threshold_uncertainty_score":0.5174205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078766693843691,"score_gpt":0.2400045495786794,"score_spread":0.2292168826402425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}