{"id":"W1983914724","doi":"10.1021/bi060017f","title":"Roles for Arg426 and Trp111 in the Modulation of NADH Oxidase Activity of the Catalase-peroxidase KatG from <i>Burkholderia pseudomallei </i>Inferred from pH-Induced Structural Changes<sup>,</sup>","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chemistry; Peroxidase; Catalase; Enzyme; Oxidase test; Oxygen; Ferric; Electron paramagnetic resonance; Oxidoreductase; Stereochemistry; Crystallography; Biochemistry; Inorganic chemistry; Nuclear magnetic resonance; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080809,0.0001880587,0.0001472759,0.00005795112,0.00008731762,0.0002786299,0.0001733652,0.0002904249,0.0004503126],"category_scores_gemma":[0.000227796,0.0001369273,0.0001448008,0.00006932687,0.0001951312,0.0001893462,0.0001572337,0.0003274375,0.0001911265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001179849,"about_ca_system_score_gemma":0.00007334648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002096001,"about_ca_topic_score_gemma":0.0001428073,"domain_scores_codex":[0.9999183,0.00001719025,0.000007669867,0.00001713264,0.00002472496,0.00001507579],"domain_scores_gemma":[0.9998785,0.00002212024,0.0000446603,0.000009693033,0.00001308447,0.00003177914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002235345,0.00001943477,0.000932405,0.00001743142,0.000003036125,0.0001315549,0.00002692266,0.00009464016,0.9978022,0.00003854199,0.00001055806,0.000699674],"study_design_scores_gemma":[0.00003103426,0.0003001606,0.03821879,0.000005362113,0.00001385193,0.0008064843,0.0001247412,0.002273569,0.957459,0.000132726,0.000617977,0.00001629879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993445,0.0001152787,0.0003371575,0.00002665959,0.000002733904,0.000001922795,0.00002511665,0.00001214694,0.0001343546],"genre_scores_gemma":[0.9994361,0.00005069137,0.0002977749,0.00001196074,0.000002211164,0.000002431154,0.00005928977,0.000004462141,0.0001350143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004503126,"threshold_uncertainty_score":0.001506448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078766693843691,"score_gpt":0.2400045495786794,"score_spread":0.2292168826402425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}