{"id":"W1983945722","doi":"10.1021/jm901457w","title":"4-Pyridylanilinothiazoles That Selectively Target von Hippel−Lindau Deficient Renal Cell Carcinoma Cells by Inducing Autophagic Cell Death","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Autophagy; Cancer research; Chemistry; Renal cell carcinoma; Clear cell renal cell carcinoma; Programmed cell death; Clear cell; In vitro; Cell; Suppressor; Cell culture; Cytotoxicity; Tumor suppressor gene; Gene; Internal medicine; Apoptosis; Biochemistry; Biology; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005690464,0.0003713886,0.0004942599,0.00006723661,0.0001223201,0.00003706531,0.0004592646,0.0003710241,0.00006656369],"category_scores_gemma":[0.00005479816,0.0003239739,0.0002846097,0.0001304277,0.00008213799,0.00001485565,0.00005522226,0.0007277387,0.000003702472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001116675,"about_ca_system_score_gemma":0.0005927381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001594934,"about_ca_topic_score_gemma":7.672039e-7,"domain_scores_codex":[0.9976982,0.00006044656,0.0006098064,0.0004246555,0.000671006,0.0005358282],"domain_scores_gemma":[0.9983085,0.00002520647,0.0006797917,0.0003013785,0.0002805415,0.000404568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002576407,0.000469764,0.0004249914,0.00007791739,0.00002696678,0.00003413176,0.0001969571,0.00006694638,0.9761081,7.797631e-7,0.02140379,0.000932057],"study_design_scores_gemma":[0.003349651,0.0005118023,0.0009887875,0.00005763747,0.0001299267,0.0003458137,0.0003192078,0.00004342929,0.9528682,0.00003365191,0.04103829,0.0003135552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723172,0.02287045,0.0008655266,0.0001778274,0.0007374201,0.0001004139,0.00003410533,0.000009903461,0.002887161],"genre_scores_gemma":[0.9929265,0.0009501908,0.0008183189,0.0005525121,0.00337637,0.000002075359,0.00004643424,0.00003296092,0.00129464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02323981,"threshold_uncertainty_score":0.9999212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008082911207415125,"score_gpt":0.2233468251749917,"score_spread":0.2152639139675765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}