{"id":"W1983969086","doi":"10.1158/1538-7445.am2011-1450","title":"Abstract 1450: Loss of the UPR member CREB3L1 is vital for the survival of breast cancer cells in the tumor microenvironment and development of the metastatic phenotype","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Cancer research; Metastasis; Cancer; Breast cancer; Unfolded protein response; Transfection; Angiogenesis; Cancer cell; Biology; Microarray analysis techniques; Tumor microenvironment; Medicine; Cell culture; Internal medicine; Endoplasmic reticulum; Gene expression; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009526091,0.0004472091,0.0003606887,0.000302253,0.0002633711,0.000295214,0.000327348,0.0003643394,0.005920595],"category_scores_gemma":[0.0001155376,0.0001808709,0.0003768706,0.0002321216,0.0003225364,0.0001493896,0.0002801386,0.0009990775,0.00220357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00052818,"about_ca_system_score_gemma":0.000372721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537591,"about_ca_topic_score_gemma":0.001466398,"domain_scores_codex":[0.9997913,0.00001350421,0.00001314024,0.00005074645,0.00008618804,0.00004511675],"domain_scores_gemma":[0.9998385,0.00001324049,0.0000512892,0.00001330743,0.00002219979,0.0000615528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006611617,0.00001266922,0.00007647056,0.00002249897,0.000002237735,0.00002810645,0.000003465399,0.00001307203,0.9991809,0.00002583222,0.00008410968,0.0004846044],"study_design_scores_gemma":[0.00001933194,0.0001424819,0.00969873,0.000009757803,0.00001650841,0.0003839305,0.00002672001,0.0007549778,0.9846637,0.00003904607,0.004236144,0.000008634142],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762174,0.003110033,0.007006455,0.0004838538,0.0002577507,0.0000658593,0.009133963,0.0006250308,0.003099671],"genre_scores_gemma":[0.969502,0.001094024,0.003429287,0.0003069854,0.00003996275,0.0001157804,0.00804427,0.0002120743,0.01725565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005920595,"threshold_uncertainty_score":0.01980633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05691617091654329,"score_gpt":0.3323913401174141,"score_spread":0.2754751692008708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}