{"id":"W1983976441","doi":"10.1021/bi8019004","title":"TβR-II Discriminates the High- and Low-Affinity TGF-β Isoforms via Two Hydrogen-Bonded Ion Pairs","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Chemistry; Affinities; Alanine; Binding site; Surface plasmon resonance; Stereochemistry; Gene isoform; Hydrogen bond; Kinetics; Ligand (biochemistry); Receptor; Crystallography; Biophysics; Biochemistry; Amino acid; Biology; Gene; Molecule; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490769,0.0004340752,0.0003372284,0.0001282609,0.00007710418,0.0003237848,0.0004397876,0.000329111,0.0008007922],"category_scores_gemma":[0.0002439312,0.0001411886,0.0002691916,0.0001113225,0.0003033838,0.0001468375,0.0001735673,0.0004379294,0.0003891136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001692937,"about_ca_system_score_gemma":0.0001186155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004466182,"about_ca_topic_score_gemma":0.0004893832,"domain_scores_codex":[0.999788,0.00004494508,0.00001846197,0.00005112264,0.00006466371,0.00003278045],"domain_scores_gemma":[0.9998011,0.00002724715,0.0000893374,0.00001217964,0.00002272823,0.00004734432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658466,0.000019797,0.000793534,0.00001733577,0.00001055071,0.00002462085,0.000007308876,0.00006628891,0.9973169,0.00002231252,0.00002438637,0.001531098],"study_design_scores_gemma":[0.00007607913,0.0004268344,0.009027204,0.000006261265,0.00003787885,0.0009292985,0.00003524527,0.00456443,0.9837611,0.00006628182,0.001055745,0.00001352166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928232,0.0006024959,0.005454133,0.00007821087,0.00002167775,0.00004087462,0.0001745226,0.0001136414,0.000691127],"genre_scores_gemma":[0.9895978,0.0002468718,0.008650522,0.0001041674,0.00001315304,0.00002144707,0.0004206143,0.00003243925,0.000913117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008007922,"threshold_uncertainty_score":0.002678931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005103498597560271,"score_gpt":0.2248530753416376,"score_spread":0.2197495767440773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}