{"id":"W1984014561","doi":"10.1074/jbc.m109.087320","title":"Protein Kinase RNA/FADD/Caspase-8 Pathway Mediates the Proapoptotic Activity of the RNA-binding Protein Human Antigen R (HuR)","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Protein kinase R; FADD; Cell biology; EIF-2 kinase; RNA-binding protein; Biology; Molecular biology; Protein kinase A; Caspase 8; RNA; Apoptosis; Chemistry; Kinase; Caspase; Cyclin-dependent kinase 2; Programmed cell death; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311254,0.0004040941,0.0001936425,0.0002062071,0.0002155043,0.0002646125,0.0001250174,0.0002162467,0.001899722],"category_scores_gemma":[0.0001264775,0.00009270296,0.0002509465,0.00008147806,0.0002106047,0.0002751083,0.0002231683,0.0004184258,0.0008785705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359293,"about_ca_system_score_gemma":0.0001919894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001376104,"about_ca_topic_score_gemma":0.0002121002,"domain_scores_codex":[0.9998691,0.00002395138,0.000006606054,0.00002517483,0.0000322155,0.00004303632],"domain_scores_gemma":[0.9999365,0.00001056006,0.0000173404,0.000008801281,0.00001145363,0.00001542142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001422384,0.00003246564,0.0002489793,0.00006542535,0.000006190399,0.0002311415,0.00002082471,0.0000764116,0.9945379,0.0006018532,0.0001244844,0.003912061],"study_design_scores_gemma":[0.00005096485,0.0003597316,0.006054436,0.00001217145,0.00001359959,0.001265678,0.00005154406,0.001659357,0.9839034,0.0006731669,0.005951077,0.000004734261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803141,0.006851427,0.006968672,0.000345002,0.00008778431,0.000032663,0.0001841373,0.0001563642,0.005059746],"genre_scores_gemma":[0.9927216,0.00158263,0.002293978,0.0000457588,0.00002699787,0.0000191358,0.0001961355,0.000006210844,0.003107592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001899722,"threshold_uncertainty_score":0.006355166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02065307783283985,"score_gpt":0.2498241110398411,"score_spread":0.2291710332070013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}