{"id":"W1984022976","doi":"10.1016/j.chembiol.2005.06.015","title":"Selective Small Molecule Peptidomimetic Ligands of TrkC and TrkA Receptors Afford Discrete or Complete Neurotrophic Activities","year":2005,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Université de Montréal; McGill University","funders":"National Cancer Institute","keywords":"Peptidomimetic; Neurotrophin; Low-affinity nerve growth factor receptor; Small molecule; Receptor; Tropomyosin receptor kinase C; Biology; Tropomyosin receptor kinase A; Combinatorial chemistry; Neuroscience; Computational biology; Pharmacology; Chemistry; Biochemistry; Platelet-derived growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009025056,0.0002600843,0.0004221608,0.00002720869,0.00006869241,0.00001315036,0.000217319,0.000269829,0.0001264541],"category_scores_gemma":[0.0001554338,0.0002087731,0.000181834,0.0001227471,0.0003748819,0.00000376593,0.0001613602,0.0001405355,0.000002035501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001839205,"about_ca_system_score_gemma":0.00004831173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001505536,"about_ca_topic_score_gemma":0.00001181479,"domain_scores_codex":[0.9987401,0.00003874141,0.0003122304,0.0005258929,0.00006120039,0.0003218134],"domain_scores_gemma":[0.9992931,0.00005883324,0.0001708278,0.0003035923,0.00005452248,0.0001191534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003097506,0.00005748097,0.0009352944,0.00005178397,0.0001317698,8.498149e-7,0.00002612777,0.000009852333,0.9961737,0.000005371216,0.0001627499,0.00213525],"study_design_scores_gemma":[0.000502505,0.0002214378,0.0001321897,0.00001753184,0.00006961155,0.00001981606,0.00006384531,0.0001570452,0.9917604,0.00002849311,0.006775731,0.0002513922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979814,0.0006307077,0.0001366404,0.0002501048,0.00002259627,0.00008611222,0.00005233301,0.00001474235,0.0008253261],"genre_scores_gemma":[0.997699,0.0005106179,0.0003519287,0.0001078281,0.0002858439,0.00001669382,0.0001472612,0.00002555679,0.0008552326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006612981,"threshold_uncertainty_score":0.8513522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138725233648077,"score_gpt":0.2359607641877083,"score_spread":0.2245735118512275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}