{"id":"W1984022976","doi":"10.1016/j.chembiol.2005.06.015","title":"Selective Small Molecule Peptidomimetic Ligands of TrkC and TrkA Receptors Afford Discrete or Complete Neurotrophic Activities","year":2005,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Université de Montréal; McGill University","funders":"National Cancer Institute","keywords":"Peptidomimetic; Neurotrophin; Low-affinity nerve growth factor receptor; Small molecule; Receptor; Tropomyosin receptor kinase C; Biology; Tropomyosin receptor kinase A; Combinatorial chemistry; Neuroscience; Computational biology; Pharmacology; Chemistry; Biochemistry; Platelet-derived growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997872,0.0004831577,0.0004133721,0.0001739354,0.0001321546,0.0004043368,0.0003201728,0.000295181,0.002071372],"category_scores_gemma":[0.0002740301,0.0002264188,0.0001689879,0.0001522865,0.0002682764,0.0003690517,0.0003449025,0.0008241676,0.0008271332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003533825,"about_ca_system_score_gemma":0.0002936487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002158127,"about_ca_topic_score_gemma":0.0005787144,"domain_scores_codex":[0.9998636,0.00001411371,0.00001084122,0.00002136035,0.00004671024,0.00004325498],"domain_scores_gemma":[0.9998852,0.00002866268,0.00002238082,0.00001101779,0.000011013,0.00004178784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003276024,0.00003319425,0.00005936542,0.00007413555,0.000007281255,0.00006766961,0.00001665668,0.0002513456,0.9906839,0.0008417174,0.0001601456,0.00747689],"study_design_scores_gemma":[0.00009951717,0.0005267921,0.0003198367,0.000005996339,0.00002159472,0.0002785134,0.00001135842,0.0005593618,0.9940537,0.0001715156,0.003944432,0.000007397588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551607,0.0068459,0.02392669,0.0002995932,0.0002247079,0.0001696472,0.0009195199,0.000530977,0.01192237],"genre_scores_gemma":[0.9777674,0.003196414,0.01057909,0.0001630956,0.00005046995,0.00009714182,0.0006847,0.00005430377,0.007407342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071372,"threshold_uncertainty_score":0.006929457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138725233648077,"score_gpt":0.2359607641877083,"score_spread":0.2245735118512275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}