{"id":"W1984025105","doi":"10.1038/nature01786","title":"P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury","year":2003,"lang":"en","type":"article","venue":"Nature","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":1538,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Deutsche Forschungsgemeinschaft; Uehara Memorial Foundation; Hospital for Sick Children; Japan Health Sciences Foundation","keywords":"Allodynia; Microglia; Nerve injury; Medicine; Peripheral nerve injury; Neuropathic pain; Neuroscience; Spinal nerve; Anesthesia; Spinal cord; Nociceptor; Receptor; Nociception; Hyperalgesia; Inflammation; Sciatic nerve; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002333716,0.0004341971,0.0006200972,0.000277753,0.0004979237,0.0005246788,0.0003266388,0.0008301361,0.005097274],"category_scores_gemma":[0.0002781914,0.0002730029,0.0005100965,0.0001757747,0.0004767051,0.0007368746,0.0004030531,0.001163376,0.001028456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003585002,"about_ca_system_score_gemma":0.0002604825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004222389,"about_ca_topic_score_gemma":0.0005403349,"domain_scores_codex":[0.9997397,0.00004687177,0.00001018375,0.00001692046,0.00003821697,0.0001481217],"domain_scores_gemma":[0.9999118,0.00001892838,0.00001786043,0.00001477125,0.00001209577,0.00002458338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001778953,0.00008493041,0.0001789922,0.0001254542,0.00001815378,0.0004396235,0.00006504622,0.00009448019,0.9931779,0.0005597582,0.0003721503,0.003104749],"study_design_scores_gemma":[0.0001887302,0.001003556,0.01411642,0.00004505727,0.00005785037,0.001060715,0.0003046084,0.001448994,0.9778079,0.001737513,0.002214747,0.00001395882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850404,0.004543833,0.002987472,0.0009928722,0.0002506693,0.00005397385,0.0001697737,0.0001032529,0.005857694],"genre_scores_gemma":[0.9907662,0.001530741,0.000858933,0.0002125068,0.0001285756,0.00006975971,0.0001011931,0.00002362152,0.0063085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005097274,"threshold_uncertainty_score":0.01705205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008003063250833758,"score_gpt":0.283805413021227,"score_spread":0.2758023497703933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}