{"id":"W1984026989","doi":"10.1016/j.euroneuro.2010.01.002","title":"Effect of hypertriglyceridemia on the pharmacokinetics and blood–brain barrier penetration of clozapine and norclozapine following administration to rats","year":2010,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Mental Health & Substance Use Services; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Clozapine; Pharmacokinetics; Hypertriglyceridemia; Pharmacology; Postprandial; Medicine; Triglyceride; Oral administration; Blood–brain barrier; Internal medicine; Central nervous system; Schizophrenia (object-oriented programming); Cholesterol; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00110065,0.0002581658,0.0004630171,0.0001235481,0.00009768912,0.00001179465,0.000125806,0.00005607898,0.00008116343],"category_scores_gemma":[0.0008990724,0.0001656118,0.00009563768,0.0002325284,0.0002450583,0.00003972351,0.0001025216,0.0005092378,0.000005911332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004624079,"about_ca_system_score_gemma":0.00001968067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002054058,"about_ca_topic_score_gemma":0.000001272017,"domain_scores_codex":[0.9979466,0.0007973567,0.0004284081,0.0003925125,0.000204069,0.0002310276],"domain_scores_gemma":[0.9979227,0.00142575,0.0001680386,0.0001939181,0.00006777435,0.0002218216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002858073,0.0001596869,0.00151522,0.0001123066,0.0001477836,0.0001525697,0.0001047766,0.000005833007,0.9831522,0.00005174414,0.001994533,0.009745273],"study_design_scores_gemma":[0.01001829,0.01828756,0.1039303,0.00006461037,0.0009356022,0.0001637954,0.00001085922,0.0004216382,0.8542916,0.000008567631,0.01160156,0.0002655748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913034,0.000194604,0.000007853914,0.005212927,0.0006903771,0.001062057,0.00001216096,0.0000520129,0.001464536],"genre_scores_gemma":[0.9929016,0.000267407,0.00008466343,0.006275944,0.0002972828,0.00002276633,0.00000368694,0.00004494157,0.0001016719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1288606,"threshold_uncertainty_score":0.6753455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304909931874595,"score_gpt":0.3224925690130984,"score_spread":0.3094434696943524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}