{"id":"W1984027363","doi":"10.1016/j.jmb.2011.04.033","title":"An Alternative Mechanism for the Catalysis of Peptide Bond Formation by L/F Transferase: Substrate Binding and Orientation","year":2011,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Transferase; Peptidyl transferase; Peptide bond; Active site; Amino acid; Stereochemistry; Peptide; Substrate (aquarium); Ribosome; Enzyme catalysis; Binding site; Enzyme; Biochemistry; Biology; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001209121,0.001261287,0.0009961488,0.0005370229,0.0009234019,0.002252942,0.002261553,0.003687057,0.003827684],"category_scores_gemma":[0.001304811,0.0007766619,0.0009214538,0.0003242485,0.001328728,0.002687826,0.001068456,0.002171355,0.001911012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001243592,"about_ca_system_score_gemma":0.001248964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006900254,"about_ca_topic_score_gemma":0.0006320932,"domain_scores_codex":[0.9992418,0.0001137538,0.00005337457,0.0002530664,0.0001059977,0.000231999],"domain_scores_gemma":[0.9993061,0.0001740312,0.0001097196,0.0001939105,0.00008043904,0.0001358209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008173286,0.0004578399,0.002493557,0.0005041083,0.00008456104,0.004957706,0.0006066366,0.001951734,0.8495746,0.09182554,0.002982896,0.04374351],"study_design_scores_gemma":[0.000289003,0.0008798997,0.001259593,0.00003117657,0.00005223432,0.004067014,0.0002341523,0.02322796,0.9446805,0.01365004,0.01144805,0.0001804286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7613866,0.002527149,0.2106671,0.005319906,0.001620558,0.0002130682,0.0003331505,0.002798789,0.0151336],"genre_scores_gemma":[0.9569491,0.0006591025,0.0344293,0.000776038,0.0001450071,0.00009760724,0.0002101465,0.0000888092,0.006644883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003827684,"threshold_uncertainty_score":0.01280493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616503197454498,"score_gpt":0.2660645811272256,"score_spread":0.2498995491526807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}