{"id":"W1984029360","doi":"10.1074/jbc.m113.479550","title":"DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA*","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"IRF3; Sendai virus; MDA5; IRF7; Ubiquitin ligase; Interferon regulatory factors; Biology; Molecular biology; Interferon; TLR3; Transcription factor; Transcription (linguistics); RNA silencing; TANK-binding kinase 1; Cell biology; Phosphorylation; RNA; Virology; Gene; RNA interference; Virus; Ubiquitin; Protein kinase A; Receptor; Toll-like receptor; Biochemistry; Cyclin-dependent kinase 2; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009444784,0.0007022319,0.0003229521,0.000285173,0.0003786767,0.000370639,0.0002277083,0.0003870241,0.002005231],"category_scores_gemma":[0.000194113,0.0002084178,0.00032917,0.0001311343,0.0003027294,0.0002865127,0.0003809611,0.0004878567,0.0009534795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006097854,"about_ca_system_score_gemma":0.0001893765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003729298,"about_ca_topic_score_gemma":0.000505433,"domain_scores_codex":[0.9998947,0.00001088883,0.000008757645,0.00003393551,0.00002807853,0.00002354238],"domain_scores_gemma":[0.9998197,0.00003069953,0.00006539353,0.00001254359,0.00001038797,0.00006128788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009822237,0.000008828715,0.0003658595,0.0000246752,0.000003485867,0.0001326617,0.000007869125,0.0000564941,0.9983894,0.00007046613,0.00003863472,0.0008034536],"study_design_scores_gemma":[0.00001423407,0.00007211045,0.01378273,0.000005892899,0.00001422213,0.0009511198,0.00005273475,0.001730975,0.9800628,0.00009553092,0.003207439,0.00001020286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911573,0.001507903,0.005294385,0.0001606029,0.00004945123,0.00002658997,0.0005648752,0.0001840347,0.001054751],"genre_scores_gemma":[0.9924632,0.0004892319,0.00277833,0.00005424041,0.00001341957,0.00003013632,0.00159331,0.00004761435,0.002530601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005231,"threshold_uncertainty_score":0.006708145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992348572770441,"score_gpt":0.2704549694163267,"score_spread":0.2405314836886223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}