{"id":"W1984031632","doi":"10.1096/fj.06-6183com","title":"Alpha‐synuclein and its disease‐causing mutants induce ICAM‐1 and IL‐6 in human astrocytes and astrocytoma cells","year":2006,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Kinexus Bioinformatics Corporation (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Neuroinflammation; Kinase; MAPK/ERK pathway; Alpha-synuclein; Cell biology; Protein kinase A; Biology; Molecular biology; p38 mitogen-activated protein kinases; Astrocyte; Inflammation; Chemistry; Immunology; Central nervous system; Parkinson's disease; Endocrinology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176548,0.0003910948,0.000189996,0.0001801221,0.0001266136,0.0001781693,0.00007170809,0.0002514149,0.0008173325],"category_scores_gemma":[0.0001091638,0.0001528179,0.0003237524,0.0001776345,0.00009907466,0.0001147203,0.0001366217,0.0002827907,0.0005440371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299768,"about_ca_system_score_gemma":0.00008928307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002457506,"about_ca_topic_score_gemma":0.0004024275,"domain_scores_codex":[0.9998388,0.00003820772,0.00002018327,0.00001840947,0.00004051589,0.00004385594],"domain_scores_gemma":[0.9999222,0.00001505877,0.00002044264,0.00001195367,0.00001092265,0.00001950504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000233058,0.00005844436,0.0002851263,0.00003158109,0.000006149877,0.0001467054,0.00001918069,0.00003118701,0.9985452,0.00003530188,0.00003880741,0.0005692596],"study_design_scores_gemma":[0.00007614761,0.001593226,0.01753229,0.00001474362,0.00004089757,0.001505064,0.00008039799,0.001168253,0.9754543,0.0001096571,0.002418914,0.000005930599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961356,0.001646681,0.0006479909,0.00006370246,0.0000299776,0.00003384948,0.0002826649,0.00003144239,0.001128221],"genre_scores_gemma":[0.9951465,0.001339899,0.001428276,0.00006852996,0.00002532627,0.00007700623,0.0007362675,0.000006831264,0.001171437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008173325,"threshold_uncertainty_score":0.002734244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727503115910725,"score_gpt":0.2568081332672364,"score_spread":0.2395331021081292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}