{"id":"W1984065470","doi":"10.1371/journal.pone.0012093","title":"ADAM10 Releases a Soluble Form of the GPNMB/Osteoactivin Extracellular Domain with Angiogenic Properties","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Association Neurofibromatoses et Recklinghause; Canadian Breast Cancer Research Alliance; Canadian Institutes of Health Research; McGill University Health Centre; Celldex Therapeutics; McGill University","keywords":"Ectodomain; Cancer research; Breast cancer; Angiogenesis; Metastasis; Cell migration; Cancer; Cancer cell; Biology; Tumor microenvironment; Medicine; Internal medicine; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863078,0.0004042941,0.0001643722,0.0001758126,0.0001134629,0.00029458,0.000135667,0.0002669226,0.001947641],"category_scores_gemma":[0.0002092417,0.00009903546,0.0003100164,0.0001030207,0.0001919773,0.0001925392,0.0001736675,0.0005182765,0.0005590831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002589932,"about_ca_system_score_gemma":0.0001878137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003637981,"about_ca_topic_score_gemma":0.0003669191,"domain_scores_codex":[0.9999011,0.00001392527,0.000009034657,0.00001817476,0.00003392864,0.00002382668],"domain_scores_gemma":[0.9998394,0.00003090506,0.00004584688,0.00002016062,0.00002428423,0.00003930894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008866838,0.00001791141,0.0004175866,0.00003879901,0.000005489981,0.0001659314,0.00001393962,0.00003501183,0.9976618,0.000061869,0.00008257334,0.00141032],"study_design_scores_gemma":[0.00003146861,0.0002697889,0.005664326,0.00001019277,0.0000157077,0.001997032,0.00003804015,0.0007576486,0.9850844,0.00007712065,0.006050487,0.000003797477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871367,0.002880895,0.007082825,0.0002478735,0.00008934311,0.00006406828,0.0007565052,0.0001105589,0.001631251],"genre_scores_gemma":[0.9878495,0.00149828,0.00534928,0.00009554432,0.00004374067,0.0000507094,0.001859937,0.00002669742,0.003226292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001947641,"threshold_uncertainty_score":0.006515503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675306367905038,"score_gpt":0.1819372128462171,"score_spread":0.1651841491671668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}