{"id":"W1984087096","doi":"10.2174/156800907780058853","title":"Phase 1 Clinical Experience Using Intravenous Administration of PV701, an Oncolytic Newcastle Disease Virus","year":2007,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Georgetown University; University of Pennsylvania","keywords":"Oncolytic virus; Medicine; Tolerability; Adverse effect; Desensitization (medicine); Regimen; Dosing; Toxicity; Pharmacology; Bolus (digestion); Phases of clinical research; Newcastle disease; Clinical trial; Internal medicine; Oncology; Virus; Cancer; Immunology; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002376453,0.001413909,0.001363612,0.0001866659,0.0006425933,0.0007723552,0.0007207061,0.0009764624,0.001944913],"category_scores_gemma":[0.001716893,0.0004022384,0.000674616,0.0002617722,0.0007415144,0.0006317385,0.000340314,0.002357771,0.000661345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001131849,"about_ca_system_score_gemma":0.001430021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002913494,"about_ca_topic_score_gemma":0.003839732,"domain_scores_codex":[0.9992374,0.0003800282,0.0000285261,0.0001291113,0.0001038545,0.0001210953],"domain_scores_gemma":[0.999008,0.0002944014,0.000136691,0.0001161135,0.0001435132,0.0003013278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1024743,0.117827,0.0253814,0.001170302,0.001316062,0.001401631,0.002255746,0.009193517,0.1872611,0.0008832457,0.02925391,0.5215817],"study_design_scores_gemma":[0.06848326,0.8359825,0.03993313,0.00008267189,0.0004229671,0.001624448,0.0001625586,0.002341519,0.02444832,0.0004137687,0.02604183,0.00006308496],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9768684,0.005363663,0.004033223,0.001071944,0.0001752278,0.003236281,0.001496718,0.0001776184,0.007576932],"genre_scores_gemma":[0.9809783,0.003926911,0.003730362,0.00131902,0.0001859474,0.001614884,0.004381772,0.00005903224,0.003803897],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002913494,"threshold_uncertainty_score":0.01256806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2442977759870614,"score_gpt":0.5522660217318367,"score_spread":0.3079682457447753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}