{"id":"W1984087096","doi":"10.2174/156800907780058853","title":"Phase 1 Clinical Experience Using Intravenous Administration of PV701, an Oncolytic Newcastle Disease Virus","year":2007,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Georgetown University; University of Pennsylvania","keywords":"Oncolytic virus; Medicine; Tolerability; Adverse effect; Desensitization (medicine); Regimen; Dosing; Toxicity; Pharmacology; Bolus (digestion); Phases of clinical research; Newcastle disease; Clinical trial; Internal medicine; Oncology; Virus; Cancer; Immunology; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006475097,0.0004914505,0.001014766,0.000139973,0.0001058594,0.00003571557,0.0006220295,0.0002595188,0.0001403621],"category_scores_gemma":[0.0001063282,0.000461655,0.0005180508,0.000248331,0.0003163074,0.00001299287,0.0001464459,0.0004367099,0.00001008213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675841,"about_ca_system_score_gemma":0.003438009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003264304,"about_ca_topic_score_gemma":0.0001823335,"domain_scores_codex":[0.996576,0.0004170056,0.001098692,0.0009213699,0.0004418219,0.0005451255],"domain_scores_gemma":[0.9976715,0.00003862585,0.0006067949,0.0008902812,0.000211005,0.0005817353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001482206,0.001610064,0.00001345684,0.002372929,0.0001054319,0.00002138391,0.00007237735,0.00001147003,0.0009847247,0.000001787992,0.0002637491,0.9930604],"study_design_scores_gemma":[0.001101696,0.002274468,0.00000485078,0.001995405,0.0003434918,0.000008330154,0.00002187041,0.0001318725,0.006093967,0.000006094606,0.9874169,0.0006010407],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06303287,0.9339581,0.0002952543,0.000005363162,0.00117851,0.0009301921,0.0005712741,0.00001403447,0.00001448107],"genre_scores_gemma":[0.006695572,0.9902052,0.0001011773,0.00002763053,0.001654764,0.0001617865,0.001012175,0.0000875807,0.00005411549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9924594,"threshold_uncertainty_score":0.9997835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2442977759870614,"score_gpt":0.5522660217318367,"score_spread":0.3079682457447753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}