{"id":"W1984101371","doi":"10.1517/17425255.2010.530656","title":"Pharmacokinetic evaluation of idebenone","year":2010,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Idebenone; Pharmacology; Chemistry; Pharmacokinetics; Metabolite; Antioxidant; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008955865,0.0008267268,0.002268434,0.0006837399,0.0001488175,0.00003787647,0.001107056,0.0004359641,0.001569636],"category_scores_gemma":[0.002277977,0.0006929777,0.0006854949,0.0006696657,0.0003867327,0.00009616916,0.0002494455,0.0008270251,0.0003361606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007620691,"about_ca_system_score_gemma":0.0008526114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006141085,"about_ca_topic_score_gemma":0.000001939289,"domain_scores_codex":[0.9907343,0.004599591,0.001238427,0.001467648,0.001371046,0.0005889562],"domain_scores_gemma":[0.9962974,0.001007708,0.00102311,0.001127274,0.0002745164,0.0002700466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000208718,0.0005368706,8.778097e-8,0.0003670864,0.00002849386,0.000002953735,0.0001393602,0.00004027628,0.04091724,0.001732616,0.00316638,0.9530478],"study_design_scores_gemma":[0.0007657111,0.00006724962,0.000008766664,0.0004189796,0.0002167412,0.00002234693,0.000006869886,0.00008738763,0.1309537,0.00011858,0.8668696,0.0004640852],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000970156,0.9841996,0.00001176886,0.000170495,0.01032777,0.002424103,0.0001600419,0.00008178836,0.001654283],"genre_scores_gemma":[0.0009269338,0.9950204,0.0001281686,0.001011985,0.001294445,0.001250983,0.00006606239,0.0001397232,0.0001613046],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9525837,"threshold_uncertainty_score":0.9995521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1454471981276215,"score_gpt":0.4364099275969944,"score_spread":0.2909627294693728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}