{"id":"W1984114045","doi":"10.1021/jm100822f","title":"Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Neuraminidase; Oseltamivir; Enzyme; Context (archaeology); Virus; Neuraminidase inhibitor; Zanamivir; Virology; Orthomyxoviridae; Influenza A virus; Biochemistry; Coronavirus disease 2019 (COVID-19); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002387356,0.0003222823,0.0008254479,0.0003339283,0.0001201245,0.00003948834,0.0005394132,0.0002188761,0.0001679765],"category_scores_gemma":[0.00321117,0.0002134705,0.0002132053,0.000803824,0.0004029174,0.0001586837,0.000154993,0.001918139,0.00004091143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001584474,"about_ca_system_score_gemma":0.000247768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001674237,"about_ca_topic_score_gemma":0.00007278142,"domain_scores_codex":[0.9958571,0.000124527,0.00144397,0.000301424,0.001692903,0.0005800924],"domain_scores_gemma":[0.9972298,0.0007286279,0.0004980811,0.0004864856,0.0004902515,0.0005667282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001644063,0.0003360483,0.01168917,0.0001636917,0.0001307395,0.0007958087,0.006288874,0.000006661778,0.9678912,0.0000512496,0.004589966,0.006412536],"study_design_scores_gemma":[0.00370568,0.001097855,0.02159795,0.0009782593,0.0001226134,0.0008282786,0.01188896,0.00000978691,0.9211942,0.00006454348,0.03826464,0.0002472575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935092,0.002566051,0.000001804324,0.002378293,0.0003248229,0.0003882787,0.00001750683,0.00001697925,0.0007970405],"genre_scores_gemma":[0.9965893,0.0002387139,0.0001862699,0.002289024,0.0005792687,0.00002043496,0.000002512364,0.00003494717,0.00005951189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04669702,"threshold_uncertainty_score":0.8705076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0361108017593644,"score_gpt":0.3482145299729519,"score_spread":0.3121037282135875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}