{"id":"W1984114045","doi":"10.1021/jm100822f","title":"Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Neuraminidase; Oseltamivir; Enzyme; Context (archaeology); Virus; Neuraminidase inhibitor; Zanamivir; Virology; Orthomyxoviridae; Influenza A virus; Biochemistry; Coronavirus disease 2019 (COVID-19); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144112,0.0003194861,0.0002743712,0.0001260015,0.0001277789,0.0001932467,0.0003511056,0.0002359405,0.001257389],"category_scores_gemma":[0.0001616356,0.00006873691,0.0001545407,0.0001755819,0.0001836704,0.0001912516,0.0001745001,0.0003500878,0.0003123617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224226,"about_ca_system_score_gemma":0.0001587638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006824814,"about_ca_topic_score_gemma":0.001494282,"domain_scores_codex":[0.9999309,0.00001220659,0.000004912513,0.00001715201,0.0000161745,0.000018634],"domain_scores_gemma":[0.9999481,0.000009262654,0.00001445538,0.00000570458,0.000007896743,0.00001464244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005218987,0.0001714274,0.0003938668,0.0005307933,0.00002420659,0.0004878766,0.0001052132,0.001066012,0.9607206,0.001458221,0.0005824192,0.03393751],"study_design_scores_gemma":[0.0003811141,0.008703439,0.006434918,0.000109953,0.0001263262,0.002364627,0.0001089992,0.003341843,0.9340799,0.0005138151,0.04378932,0.00004586024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9430175,0.04044727,0.006132426,0.0001602926,0.0001978944,0.0002759792,0.0002671603,0.0001594886,0.009342085],"genre_scores_gemma":[0.9774662,0.01289202,0.005216176,0.000145827,0.00003855391,0.00008200046,0.0003939351,0.00001372191,0.003751533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257389,"threshold_uncertainty_score":0.004206359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0361108017593644,"score_gpt":0.3482145299729519,"score_spread":0.3121037282135875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}