{"id":"W1984116490","doi":"10.1016/s2213-2600(14)70294-2","title":"Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Cancer Institute; National Institute on Drug Abuse; National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Varenicline; Placebo; Medicine; Cotinine; Nicotine; Nicotine patch; Clinical endpoint; Smoking cessation; Adverse effect; Pill; Randomized controlled trial; Abstinence; Internal medicine; Clinical trial; Pharmacology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002437941,0.003069214,0.007313827,0.0007042664,0.0008592276,0.001483064,0.001351929,0.006038978,0.007133638],"category_scores_gemma":[0.003153233,0.001294011,0.003414106,0.0005850293,0.002235306,0.001960052,0.0007145869,0.004539044,0.001381584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007754368,"about_ca_system_score_gemma":0.0006638267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00118758,"about_ca_topic_score_gemma":0.001303088,"domain_scores_codex":[0.9985379,0.0006818784,0.0001075049,0.0004122185,0.0001031956,0.0001572899],"domain_scores_gemma":[0.998317,0.0006465571,0.0002994087,0.0001818659,0.0001458361,0.0004093553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9930897,0.001694483,0.0003119239,0.0002748331,0.0008881489,0.00001563566,0.00002060707,0.00004949772,0.0009749487,0.00003208786,0.0001197632,0.002528362],"study_design_scores_gemma":[0.9538487,0.04251175,0.001630623,0.00003073251,0.00109975,0.00001454173,0.00001759517,0.0001916383,0.0002430157,0.0001293351,0.000258935,0.00002339275],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759725,0.009992779,0.001867316,0.001065473,0.002492792,0.005250676,0.001206663,0.0002225801,0.001929235],"genre_scores_gemma":[0.9831197,0.003569148,0.001883689,0.001466237,0.001263389,0.00455613,0.0008058554,0.00004568831,0.003290227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007313827,"threshold_uncertainty_score":0.02386439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1504023320851682,"score_gpt":0.3842179093813497,"score_spread":0.2338155772961815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}