{"id":"W1984138060","doi":"10.2217/fnl.15.3","title":"Conquering the barriers: are antibody therapeutics feasible for CNS indications?","year":2015,"lang":"en","type":"article","venue":"Future Neurology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Medicine; Antibody; Intensive care medicine; Neuroscience; Immunology; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000233763,0.0001234514,0.0002092747,0.00007074268,0.0001860118,0.00001848878,0.0001907926,0.0001372007,0.00007397223],"category_scores_gemma":[0.0001190042,0.00007461284,0.00008189367,0.0001506836,0.0001804621,0.00003441452,0.00006293553,0.0003867809,0.00004858846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001138044,"about_ca_system_score_gemma":0.0001909256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002010554,"about_ca_topic_score_gemma":0.00002029005,"domain_scores_codex":[0.9989986,0.00009226397,0.0001560279,0.0002200275,0.0002096708,0.0003233492],"domain_scores_gemma":[0.9990581,0.0001884398,0.00006906223,0.0002850725,0.0001807063,0.0002186084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009100961,0.0004153685,0.7245847,0.0003647138,0.0007549677,0.0003330211,0.00412729,0.00007776105,0.01977579,0.04657938,0.1791236,0.01476247],"study_design_scores_gemma":[0.000988157,0.0008508372,0.05132329,0.000006100315,0.0000517267,0.0002524911,0.0003419828,0.0004179712,0.0004570856,0.0009726039,0.9442536,0.00008410483],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7303169,0.002460545,0.0004682959,0.2606617,0.001266105,0.0009702186,0.00006858117,0.00008206839,0.003705505],"genre_scores_gemma":[0.9647723,0.0003227498,0.0002997668,0.02979962,0.002871571,0.00008631199,0.00009280642,0.00003344571,0.001721386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7651301,"threshold_uncertainty_score":0.3042623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07095664374648364,"score_gpt":0.3730119451625133,"score_spread":0.3020553014160297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}