{"id":"W1984146496","doi":"10.1107/s1744309109038718","title":"Purification, crystallization and preliminary X-ray analysis of bifunctional isocitrate dehydrogenase kinase/phosphatase in complex with its substrate, isocitrate dehydrogenase, from<i>Escherichia coli</i>","year":2009,"lang":"en","type":"article","venue":"Acta Crystallographica Section F Structural Biology and Crystallization Communications","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Isocitrate dehydrogenase; Dehydrogenase; Phosphofructokinase 2; Bifunctional; Substrate (aquarium); Escherichia coli; Biochemistry; IDH1; Biology; Chemistry; Crystallography; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004217053,0.000429435,0.0005409899,0.0002101076,0.0003663845,0.0005201441,0.0006316213,0.0002675387,0.0006198298],"category_scores_gemma":[0.0004051684,0.0002534882,0.0003223022,0.0008615601,0.0002331732,0.000242029,0.000224423,0.0009535936,0.0004518414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008654675,"about_ca_system_score_gemma":0.0004517811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004230824,"about_ca_topic_score_gemma":0.00368,"domain_scores_codex":[0.9997885,0.00003908229,0.00002459826,0.00003843262,0.00007334522,0.00003616148],"domain_scores_gemma":[0.9998376,0.00003214495,0.00002054199,0.0000302347,0.0000492896,0.00003014927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003944251,0.0001998698,0.001037259,0.0002506458,0.00003270244,0.0002991733,0.0001737238,0.001153977,0.9901583,0.0006315347,0.000577713,0.005090625],"study_design_scores_gemma":[0.00005223911,0.0001450748,0.007534487,0.00001278482,0.0000368234,0.0005454426,0.00009921158,0.003260624,0.9771017,0.0001902568,0.01100418,0.00001716171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761474,0.003819577,0.01155294,0.0004575162,0.00007202684,0.0001749537,0.004988378,0.0001438733,0.002643517],"genre_scores_gemma":[0.9333196,0.006514328,0.03452387,0.0001215395,0.00003615142,0.0001593351,0.01889525,0.0001787206,0.006251173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004230824,"threshold_uncertainty_score":0.008412421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0159821236544539,"score_gpt":0.2505888403252772,"score_spread":0.2346067166708233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}