{"id":"W1984161746","doi":"10.1158/1538-7445.am2011-1703","title":"Abstract 1703: Importance of pregnane X receptor (PXR) and P-glycoprotein (MDR1) to tamoxifen response and endoxifen disposition","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Pregnane X receptor; Tamoxifen; Pharmacology; Estrogen receptor; CYP3A4; Abcg2; P-glycoprotein; Breast cancer; Biology; Internal medicine; Endocrinology; Chemistry; Cytochrome P450; Nuclear receptor; Cancer; Multiple drug resistance; Transporter; Medicine; Drug resistance; Biochemistry; ATP-binding cassette transporter; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001937441,0.0001993114,0.0004273871,0.0002125191,0.0001181433,0.0004014994,0.0001333258,0.000409644,0.002794858],"category_scores_gemma":[0.000265419,0.0001309404,0.0002443663,0.0002477851,0.0001581615,0.0002593612,0.0001088318,0.0005694692,0.0006620564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456143,"about_ca_system_score_gemma":0.0001988158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006938743,"about_ca_topic_score_gemma":0.0004436422,"domain_scores_codex":[0.9997943,0.00004563434,0.00001813926,0.00003096621,0.00006089052,0.00005012449],"domain_scores_gemma":[0.9998522,0.00003350944,0.00004299527,0.00001308227,0.00002564325,0.00003255512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006654684,0.00006945084,0.002751552,0.00004423313,0.000009578574,0.0001862162,0.00002241261,0.00003469171,0.9936249,0.00005815106,0.0001028247,0.002430453],"study_design_scores_gemma":[0.00007823187,0.001802839,0.1225342,0.00001848766,0.00005611894,0.002628087,0.0002227658,0.001158107,0.8668504,0.0001211908,0.004513448,0.00001622118],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958544,0.001701701,0.0006469893,0.0002071003,0.00002212759,0.00002151575,0.0004897084,0.00002460844,0.001032049],"genre_scores_gemma":[0.9963349,0.0006121728,0.0005110307,0.0001053156,0.00001905101,0.00002797035,0.0006888771,0.00001205479,0.001688574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002794858,"threshold_uncertainty_score":0.009349763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03575237916178119,"score_gpt":0.3388232633287857,"score_spread":0.3030708841670045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}