{"id":"W1984165805","doi":"10.1126/science.1188888","title":"<i>Staphylococcus aureus</i> Nonribosomal Peptide Secondary Metabolites Regulate Virulence","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Nonribosomal peptide; Staphylococcus aureus; Virulence; Microbiology; Antibiotics; Pathogen; Biology; Virulence factor; Spleen; Staphylococcal infections; Clearance; Human pathogen; Sortase A; In vivo; Bacteria; Medicine; Immunology; Gene; Biotechnology; Biochemistry; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140082,0.000325385,0.0001976684,0.0002271094,0.0001441536,0.0007440612,0.0001629698,0.0003640991,0.00398438],"category_scores_gemma":[0.0001922801,0.00009101912,0.0001028338,0.0001661785,0.0002544617,0.0002311097,0.0002638409,0.0003153912,0.001658299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003311087,"about_ca_system_score_gemma":0.0001260166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003349808,"about_ca_topic_score_gemma":0.0007929617,"domain_scores_codex":[0.9998983,0.00001837498,0.000006664338,0.0000209614,0.0000351308,0.00002048607],"domain_scores_gemma":[0.9998648,0.00002232281,0.00004075329,0.00001024866,0.00003068961,0.00003114248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004226789,0.00003557784,0.00174881,0.0001685396,0.000009656125,0.0003817033,0.00004909335,0.0002048883,0.9685922,0.001553754,0.007189592,0.01964343],"study_design_scores_gemma":[0.00006223588,0.0005003009,0.05776374,0.00009702772,0.00003185939,0.00184041,0.0002188514,0.002395689,0.8662363,0.002889977,0.06793891,0.0000246792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.846617,0.06266075,0.009872034,0.009395499,0.001344707,0.00009226805,0.003147173,0.001008464,0.06586213],"genre_scores_gemma":[0.9696683,0.01094131,0.002523338,0.001158398,0.0004744736,0.00002239038,0.001229458,0.0000931161,0.01388924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00398438,"threshold_uncertainty_score":0.01332909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00811784803238469,"score_gpt":0.2659887234034125,"score_spread":0.2578708753710278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}