{"id":"W1984165805","doi":"10.1126/science.1188888","title":"<i>Staphylococcus aureus</i> Nonribosomal Peptide Secondary Metabolites Regulate Virulence","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Nonribosomal peptide; Staphylococcus aureus; Virulence; Microbiology; Antibiotics; Pathogen; Biology; Virulence factor; Spleen; Staphylococcal infections; Clearance; Human pathogen; Sortase A; In vivo; Bacteria; Medicine; Immunology; Gene; Biotechnology; Biochemistry; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0009545979,0.0002916764,0.0003991945,0.0002989915,0.0004686512,0.0001469885,0.0008245534,0.0001280265,0.0005733384],"category_scores_gemma":[0.0006974601,0.0002487994,0.0001632956,0.001417843,0.002995038,0.0006363454,0.0002469152,0.0008180051,0.0003283155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006171356,"about_ca_system_score_gemma":0.001198753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003189037,"about_ca_topic_score_gemma":0.00007134196,"domain_scores_codex":[0.9968756,0.00002347973,0.0004045771,0.0008697205,0.0009017678,0.0009248207],"domain_scores_gemma":[0.9976274,0.00009437162,0.0001647065,0.001139722,0.0004576821,0.0005161226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006298109,0.00006783194,0.007650137,0.00003511818,0.000009270696,0.0000562061,0.0001382826,0.000001755496,0.9850396,0.00223299,0.001355295,0.003350528],"study_design_scores_gemma":[0.000644449,0.00009416352,0.1525158,0.00007368579,0.00004477004,0.00006615348,0.00008499737,0.00008908662,0.7593196,0.001129298,0.08558226,0.0003557322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721073,0.0003454793,0.0003013169,0.0009047347,0.0009895294,0.0004288589,0.00004111661,0.0001793046,0.02470238],"genre_scores_gemma":[0.9789096,0.00003558411,0.01607353,0.001534639,0.0003463094,0.00001899562,0.000005163704,0.00003129934,0.003044949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.22572,"threshold_uncertainty_score":0.9999964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00811784803238469,"score_gpt":0.2659887234034125,"score_spread":0.2578708753710278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}