{"id":"W1984171106","doi":"10.1002/hep.24269","title":"Hepatic autophagy mediates endoplasmic reticulum stress–induced degradation of misfolded apolipoprotein B","year":2011,"lang":"en","type":"article","venue":"Hepatology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Endoplasmic reticulum; Autophagy; Unfolded protein response; Cell biology; Endoplasmic-reticulum-associated protein degradation; Protein folding; Degradation (telecommunications); Chemistry; Biology; Biochemistry; Apoptosis; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396293,0.0003306794,0.0002691297,0.0001031651,0.0002028436,0.0002330661,0.0001862618,0.0002375433,0.002327763],"category_scores_gemma":[0.00009373303,0.00009106097,0.0002094075,0.0001096043,0.0002911046,0.0001953784,0.0001924413,0.0002812259,0.0008642133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469131,"about_ca_system_score_gemma":0.0001978295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372933,"about_ca_topic_score_gemma":0.0004034519,"domain_scores_codex":[0.9999126,0.00001848125,0.00001005727,0.00001738071,0.00001436592,0.00002703637],"domain_scores_gemma":[0.9999304,0.000009073431,0.0000199794,0.00001061348,0.00001046066,0.000019371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009512995,0.00003992402,0.0003735205,0.0001827032,0.000007309827,0.0002241767,0.00001927833,0.00004325615,0.9958546,0.0001349958,0.0001383408,0.002030592],"study_design_scores_gemma":[0.00007043068,0.0005062079,0.01060493,0.00001563578,0.00003089046,0.0008330348,0.00007187783,0.0009612081,0.98242,0.0001047205,0.004374031,0.000007023626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911618,0.00366918,0.002163116,0.0001837462,0.00009044325,0.00003739647,0.0003274321,0.0001390951,0.002227657],"genre_scores_gemma":[0.9932253,0.001593882,0.001061553,0.00005757453,0.00005131226,0.00003323665,0.0004438503,0.00001909046,0.003514295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002327763,"threshold_uncertainty_score":0.007787168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889198774582327,"score_gpt":0.2347387890161307,"score_spread":0.2158468012703074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}