{"id":"W1984171856","doi":"10.1371/journal.ppat.0020026","title":"The Expanding Universe of Prion Diseases","year":2006,"lang":"en","type":"review","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of California, San Francisco","keywords":"Chronic wasting disease; Bovine spongiform encephalopathy; Disease; Virology; Outbreak; Fatal familial insomnia; Biology; Transmissible spongiform encephalopathy; Scrapie; Tropism; Kuru; Prion protein; Virus; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006774063,0.001182982,0.001363371,0.00176834,0.0004612318,0.001371499,0.001022225,0.00169935,0.003810837],"category_scores_gemma":[0.0008488961,0.0002309062,0.0003233064,0.002462638,0.0008268069,0.002641347,0.0007530004,0.001580056,0.00428139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007426915,"about_ca_system_score_gemma":0.001385504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025193,"about_ca_topic_score_gemma":0.001175345,"domain_scores_codex":[0.9997585,0.00005063124,0.00002247637,0.00004027603,0.0001091661,0.00001887476],"domain_scores_gemma":[0.9996269,0.0001489685,0.00003918609,0.00002134174,0.00009852106,0.0000650547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005507138,0.00004290837,0.0002104952,0.006717119,0.0000481864,0.0005504345,0.0001517739,0.0003796057,0.002204315,0.007467274,0.06490908,0.9172637],"study_design_scores_gemma":[0.000008955076,0.00003242588,0.0003823654,0.0009477818,0.00001840753,0.00121167,0.00006035198,0.00004413231,0.000169155,0.003023382,0.9940924,0.000009036646],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001262481,0.9964825,0.0002367615,0.0005664789,0.0004385356,0.000003513627,0.0000119138,0.00001435572,0.002119529],"genre_scores_gemma":[0.0007844316,0.9968728,0.0002890282,0.0003185132,0.0004145366,0.000005074965,0.00002139348,0.000001906732,0.001292331],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003810837,"threshold_uncertainty_score":0.01274848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502083261469289,"score_gpt":0.2932853627126379,"score_spread":0.268264530097945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}