{"id":"W1984171856","doi":"10.1371/journal.ppat.0020026","title":"The Expanding Universe of Prion Diseases","year":2006,"lang":"en","type":"review","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of California, San Francisco","keywords":"Chronic wasting disease; Bovine spongiform encephalopathy; Disease; Virology; Outbreak; Fatal familial insomnia; Biology; Transmissible spongiform encephalopathy; Scrapie; Tropism; Kuru; Prion protein; Virus; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008357827,0.000237279,0.0004436868,0.00004261512,0.0001535368,0.00002350846,0.0003170579,0.0001767674,0.00001251032],"category_scores_gemma":[0.0001025995,0.0001632052,0.0005379659,0.0001059503,0.00007506338,0.00000176393,0.0002487824,0.00008290259,0.00000807026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002275988,"about_ca_system_score_gemma":0.0001910116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002879347,"about_ca_topic_score_gemma":0.000002313124,"domain_scores_codex":[0.9988735,0.0001391715,0.0003157555,0.0003017279,0.000147984,0.0002218542],"domain_scores_gemma":[0.9990246,0.00004694103,0.0003009447,0.0004980094,0.0000509754,0.00007847679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001167596,0.00005879805,0.00002576739,0.002379278,0.0001574639,0.000008943778,0.000003030811,0.000001526347,0.001484547,0.00006814612,0.0007124453,0.9950884],"study_design_scores_gemma":[0.00008497662,0.00004863985,0.000007286642,0.001364265,0.000641286,0.000003626849,0.00001272778,0.000001865805,0.0003458379,0.00002887265,0.9972541,0.0002064818],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003120382,0.9984409,0.00004233365,0.000004023701,0.00008207175,0.0004252509,0.0004670972,0.00001107312,0.0002152409],"genre_scores_gemma":[0.0002802519,0.9985539,0.00005948194,0.000006046185,0.0002628666,0.00004874423,0.0005078127,0.000039573,0.0002413411],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9965417,"threshold_uncertainty_score":0.6655316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502083261469289,"score_gpt":0.2932853627126379,"score_spread":0.268264530097945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}