{"id":"W1984183824","doi":"10.4155/fmc.12.138","title":"C8-Linked Bulky Guanosine DNA Adducts: Experimental And Computational Insights Into Adduct Conformational Preferences And Resulting Mutagenicity","year":2012,"lang":"en","type":"review","venue":"Future Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Adduct; Nucleobase; Guanine; DNA; Chemistry; Guanosine; Stereochemistry; Covalent bond; DNA adduct; Biochemistry; Nucleotide; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003258954,0.0007430465,0.001083913,0.0003628453,0.0001828125,0.0005057843,0.0006534047,0.0005893821,0.001555666],"category_scores_gemma":[0.000322324,0.0002976609,0.0003789183,0.0008170584,0.0002499164,0.0006833135,0.0003808069,0.000623653,0.0008926347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003593976,"about_ca_system_score_gemma":0.0005140028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008501488,"about_ca_topic_score_gemma":0.001410225,"domain_scores_codex":[0.9999199,0.00001638269,0.000004811373,0.00001955015,0.0000300638,0.000009361337],"domain_scores_gemma":[0.9998895,0.00005616525,0.00001679095,0.000006733286,0.0000243941,0.000006401815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002395323,0.0001904282,0.0010735,0.02534591,0.0003130437,0.0004690092,0.0001568061,0.1006001,0.04053686,0.03350627,0.01673869,0.7808299],"study_design_scores_gemma":[0.0001455383,0.001160123,0.003295732,0.002770536,0.0007680783,0.001912019,0.0002594576,0.1148186,0.09439092,0.04404888,0.7361787,0.0002514547],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02237909,0.9545844,0.01348125,0.0004594997,0.0001698175,0.00002261708,0.0002181604,0.0001875856,0.008497575],"genre_scores_gemma":[0.05807901,0.9268259,0.01155362,0.0001340357,0.0001140281,0.00005545773,0.0003403893,0.0000677304,0.002829826],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001555666,"threshold_uncertainty_score":0.005204201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907914096949724,"score_gpt":0.288032041287054,"score_spread":0.2689529003175568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}