{"id":"W1984183824","doi":"10.4155/fmc.12.138","title":"C8-Linked Bulky Guanosine DNA Adducts: Experimental And Computational Insights Into Adduct Conformational Preferences And Resulting Mutagenicity","year":2012,"lang":"en","type":"review","venue":"Future Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Adduct; Nucleobase; Guanine; DNA; Chemistry; Guanosine; Stereochemistry; Covalent bond; DNA adduct; Biochemistry; Nucleotide; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001808037,0.0006188746,0.0008300481,0.00003700709,0.0002324028,0.00004969643,0.0002982984,0.0007886151,0.000140577],"category_scores_gemma":[0.00007442493,0.0005047269,0.0001480567,0.00008703924,0.0004130908,0.00001906236,0.0003092113,0.0005102849,0.00000586408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005596518,"about_ca_system_score_gemma":0.000276396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006245986,"about_ca_topic_score_gemma":0.000001017372,"domain_scores_codex":[0.9978906,0.00003755439,0.0006672796,0.0006613847,0.0003978112,0.0003453751],"domain_scores_gemma":[0.9987289,0.0000522014,0.0004532918,0.000316698,0.0001172456,0.0003316992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004428058,0.0006338528,0.0001169953,0.06052734,0.001972707,0.00007090819,0.003213559,0.000003430012,0.3327495,0.0001436706,0.01203969,0.5880855],"study_design_scores_gemma":[0.00078877,0.00008674183,0.00002719791,0.001479632,0.0004080219,0.0005717491,0.0007068251,0.00001443848,0.03134743,0.00003163404,0.9638433,0.0006942258],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09595302,0.9022004,0.00001706283,0.00004601166,0.0002544537,0.0002194056,0.00008448419,0.00002532689,0.00119981],"genre_scores_gemma":[0.1197585,0.8655663,0.00077437,0.0001334913,0.006335841,0.00007347351,0.00697669,0.00006539239,0.0003159577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9518036,"threshold_uncertainty_score":0.9997404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907914096949724,"score_gpt":0.288032041287054,"score_spread":0.2689529003175568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}