{"id":"W1984185325","doi":"10.1371/journal.pone.0045918","title":"Lamin A/C Mutants Disturb Sumo1 Localization and Sumoylation in Vitro and in Vivo","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Foreign Affairs and International Trade Canada; Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; University of Ottawa; Heart and Stroke Foundation of Canada","keywords":"SUMO protein; Lamin; C2C12; Cell biology; Mutant; Biology; LMNA; Progeria; Intermediate filament; Nuclear lamina; Mutation; Molecular biology; Ubiquitin; Myocyte; Genetics; Nuclear protein; Cytoskeleton; Cell; Myogenesis; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006265551,0.0000523916,0.00006567105,0.00003270546,0.00001666975,0.00000768382,0.00001469119,0.00007189744,0.000007143512],"category_scores_gemma":[0.00002776597,0.00005206053,0.000004980105,0.00004938086,0.00001944001,0.000007651471,0.00002220919,0.00003569711,8.943971e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007651019,"about_ca_system_score_gemma":0.000003366159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001914268,"about_ca_topic_score_gemma":0.00008268203,"domain_scores_codex":[0.999649,0.00002105985,0.00007638527,0.0001061966,0.00004896822,0.00009839667],"domain_scores_gemma":[0.9998767,0.00000386502,0.0000203839,0.0000611041,0.00001035278,0.0000276256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008388638,0.00007959174,0.1739018,0.00001895307,0.000007038426,3.239401e-7,0.0000800046,0.000001477853,0.8249505,0.00001383568,0.00001425552,0.0008482771],"study_design_scores_gemma":[0.0005387981,0.00005484792,0.270748,0.00002302744,0.00001640834,0.000002730687,0.00005436506,0.0006748265,0.7271847,0.00006711169,0.0005206385,0.0001145204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990878,0.000421908,0.0001038906,0.00003189614,0.00002152922,0.000084433,0.000004638063,0.000003501708,0.000240449],"genre_scores_gemma":[0.9993975,0.0001454888,0.0001968389,0.00006387488,0.00007958391,0.000003641087,0.00003940815,0.000007552584,0.00006609406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09776579,"threshold_uncertainty_score":0.2122967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189114653469984,"score_gpt":0.199175407449899,"score_spread":0.1872842609151991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}