{"id":"W1984185325","doi":"10.1371/journal.pone.0045918","title":"Lamin A/C Mutants Disturb Sumo1 Localization and Sumoylation in Vitro and in Vivo","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Foreign Affairs and International Trade Canada; Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; University of Ottawa; Heart and Stroke Foundation of Canada","keywords":"SUMO protein; Lamin; C2C12; Cell biology; Mutant; Biology; LMNA; Progeria; Intermediate filament; Nuclear lamina; Mutation; Molecular biology; Ubiquitin; Myocyte; Genetics; Nuclear protein; Cytoskeleton; Cell; Myogenesis; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000260421,0.000474433,0.0002886604,0.0002958759,0.0003518308,0.0004266752,0.0004247629,0.0004328815,0.00113693],"category_scores_gemma":[0.0001967758,0.0002971536,0.0003140623,0.0002351015,0.0003187851,0.0002091623,0.0002550504,0.0005864285,0.0005087529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008148017,"about_ca_system_score_gemma":0.0003346191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004308358,"about_ca_topic_score_gemma":0.005083658,"domain_scores_codex":[0.9997185,0.00005351249,0.00004075343,0.00006470771,0.00006576502,0.00005676148],"domain_scores_gemma":[0.9996492,0.00006760184,0.0001069602,0.00005474078,0.00002691099,0.00009456592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001058476,0.00002736989,0.00009249678,0.00001388533,0.000005633248,0.00003400934,0.00001783969,0.00006467418,0.9993175,0.00006619752,0.00002423198,0.0002302424],"study_design_scores_gemma":[0.000009365418,0.0001396135,0.001648993,0.000002893777,0.000008600422,0.0001486922,0.00002538671,0.0005766143,0.9966306,0.00002829468,0.0007759985,0.000004905863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968756,0.0005350297,0.001292727,0.0000728715,0.00002561983,0.00001117411,0.0003322459,0.00007816361,0.0007764319],"genre_scores_gemma":[0.9944901,0.000491627,0.001537004,0.00003889267,0.000007001219,0.00002318422,0.0006546121,0.00006278417,0.002694827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004308358,"threshold_uncertainty_score":0.008566618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189114653469984,"score_gpt":0.199175407449899,"score_spread":0.1872842609151991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}