{"id":"W1984209384","doi":"10.1371/journal.pone.0052535","title":"Genome-Wide Search for Gene-Gene Interactions in Colorectal Cancer","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Toronto General Hospital; Ottawa Hospital; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Canadian Institutes of Health Research; U.S. Public Health Service; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Association Anne de Bretagne Genetique; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Ontario Ministry of Economic Development and Innovation; Canadian Cancer Society Research Institute; National Institutes of Health; U.S. Department of Health and Human Services; Office of Dietary Supplements; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Ministero dello Sviluppo Economico; Division of Cancer Prevention, National Cancer Institute; Ministerio de Economía y Competitividad; National Human Genome Research Institute; Conseil Régional des Pays de la Loire; Ontario Institute for Cancer Research","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Genetics; Biology; Missing heritability problem; Genetic association; Colorectal cancer; Locus (genetics); Genome; Gene; Computational biology; Cancer; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00385798,0.0007329237,0.001884882,0.003057802,0.0009714562,0.0008303516,0.001147827,0.001023086,0.003727578],"category_scores_gemma":[0.005707853,0.0003921629,0.002905367,0.003785085,0.000609809,0.0003054255,0.001239243,0.001265735,0.0004213533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163075,"about_ca_system_score_gemma":0.0009169657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002223522,"about_ca_topic_score_gemma":0.00426273,"domain_scores_codex":[0.9967645,0.001072659,0.000276503,0.00117493,0.0004813416,0.0002299458],"domain_scores_gemma":[0.9940573,0.004158899,0.000818978,0.0003395662,0.0001834345,0.0004418556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003765976,0.0004491847,0.837768,0.0006549507,0.01179483,0.004459711,0.0003899642,0.003323422,0.09616305,0.001372668,0.001773613,0.03808458],"study_design_scores_gemma":[0.0003913471,0.001098078,0.9717526,0.00003679541,0.003952923,0.003330569,0.000156516,0.009902194,0.004677292,0.001543167,0.003101552,0.00005700643],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815954,0.003188436,0.01151467,0.0004367726,0.00003594519,0.0001043815,0.001892387,0.0003432974,0.0008888527],"genre_scores_gemma":[0.9870282,0.0003619196,0.009788278,0.0002497499,0.00005573465,0.00007507352,0.002161103,0.00004017017,0.0002396714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00385798,"threshold_uncertainty_score":0.02040321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0583921297324105,"score_gpt":0.3096442004592997,"score_spread":0.2512520707268893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}