{"id":"W1984211142","doi":"10.1021/ol800050g","title":"Benzofuran-Derived Cyclic β-Amino Acid Scaffold for Building a Diverse Set of Flavonoid-Like Probes and the Discovery of a Cell Motility Inhibitor","year":2008,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Steacie Institute for Molecular Sciences; University of Ottawa; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Benzofuran; Chemistry; Motility; Scaffold; Amino acid; Flavonoid; IC50; Cell; Combinatorial chemistry; Stereochemistry; Biochemistry; In vitro; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400872,0.000354006,0.0002294507,0.0001738976,0.0001274219,0.0001710593,0.0002657102,0.0002116211,0.0008114766],"category_scores_gemma":[0.000112817,0.0001049105,0.0001511264,0.0001853579,0.0001932156,0.0002066602,0.0001568815,0.0003208928,0.0004011631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00023147,"about_ca_system_score_gemma":0.0002652513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004069886,"about_ca_topic_score_gemma":0.001087499,"domain_scores_codex":[0.9999467,0.00001038038,0.000002624725,0.00001134158,0.00001422318,0.00001479146],"domain_scores_gemma":[0.9999533,0.00000635865,0.0000154664,0.000006272103,0.000006932985,0.00001169754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006950699,0.00002610555,0.0001404096,0.00007280631,0.000006518953,0.0001608504,0.00003093746,0.0004426602,0.9899809,0.0007076355,0.00007707411,0.008284582],"study_design_scores_gemma":[0.00003797305,0.0006620862,0.0009132686,0.00001094108,0.00002289617,0.0006554716,0.00002137518,0.0008304013,0.9846193,0.0001826515,0.01202928,0.00001426769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439449,0.009126838,0.03599043,0.0004182432,0.00005832893,0.0001758519,0.000476014,0.0001764086,0.00963308],"genre_scores_gemma":[0.957028,0.005800274,0.03374093,0.0001193575,0.00003164152,0.00007146021,0.0003664813,0.00002595624,0.002815932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008114766,"threshold_uncertainty_score":0.002714694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008243760337559882,"score_gpt":0.2020515208580314,"score_spread":0.1938077605204716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}