{"id":"W1984214335","doi":"10.1515/bc.2003.157","title":"Transcription of Cathepsin B in Glioma Cells: Regulation by an E-Box Adjacent to the Transcription Initiation Site","year":2003,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"National Cancer Institute; U.S. Forest Service; National Institutes of Health","keywords":"Molecular biology; Chromatin immunoprecipitation; Transcription factor; Promoter; Transcription (linguistics); Enhancer; Transactivation; E-box; Transfection; Biology; Chemistry; Gene expression; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002709108,0.0001308523,0.0001176915,0.00001420582,0.00004070034,0.00001302759,0.0001345739,0.0002408781,0.0000412023],"category_scores_gemma":[0.0000374414,0.000101175,0.00006414847,0.0001123192,0.00004432883,0.000004529883,0.00001178802,0.0000741285,0.000002728029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003115976,"about_ca_system_score_gemma":0.00002273456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001384513,"about_ca_topic_score_gemma":0.00002329933,"domain_scores_codex":[0.9990959,0.00009069622,0.0002714069,0.0002910193,0.00008516467,0.0001658751],"domain_scores_gemma":[0.9995683,0.000007062475,0.00007970118,0.0002387331,0.00004699292,0.00005913994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006016367,0.0001271024,0.0005540911,0.00001602448,0.000004902747,3.154603e-7,0.0001040033,0.0004472238,0.9981982,0.000030434,0.0001262501,0.0003312727],"study_design_scores_gemma":[0.0003409753,0.0001638845,0.003204291,0.000008085371,0.000006360528,0.000004861762,0.0001199847,0.0002541167,0.9912111,0.0001050156,0.004444437,0.0001369167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996342,0.0002556275,0.002689552,0.00008813399,0.00005446426,0.0001847349,0.00007500105,0.000007962447,0.0003025061],"genre_scores_gemma":[0.9985625,0.0000936412,0.0004787353,0.00008254911,0.00004604215,0.00002536555,0.000642786,0.000009729803,0.00005869199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006987145,"threshold_uncertainty_score":0.4125797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389901449961953,"score_gpt":0.221988286156501,"score_spread":0.2080892716568815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}