{"id":"W1984247031","doi":"10.1016/j.bone.2011.01.019","title":"FOXO1 modulates osteoblast differentiation","year":2011,"lang":"en","type":"article","venue":"Bone","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences","keywords":"Gene knockdown; FOXO1; Osteoblast; Chromatin immunoprecipitation; RUNX2; Downregulation and upregulation; Transfection; Osteocalcin; Chemistry; Alkaline phosphatase; Cell biology; Biology; Cell culture; Endocrinology; In vitro; Gene expression; Signal transduction; Apoptosis; Promoter; Biochemistry; Enzyme; Gene; Protein kinase B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216671,0.0002930787,0.0003199086,0.000340069,0.0003656165,0.0005551163,0.0002262343,0.0004004843,0.004425276],"category_scores_gemma":[0.0001977874,0.0002650374,0.0003603354,0.0002905273,0.0005331747,0.0003669658,0.0004644147,0.0007310295,0.0005308358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007572471,"about_ca_system_score_gemma":0.0005312713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476466,"about_ca_topic_score_gemma":0.003685171,"domain_scores_codex":[0.9998356,0.00001579402,0.000009683285,0.00003702656,0.0000327422,0.00006916324],"domain_scores_gemma":[0.9999026,0.00001125454,0.00002326052,0.00001159268,0.00001217969,0.00003913412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008375381,0.00004123423,0.0004228839,0.00007389348,0.00001009485,0.00005032585,0.00002294958,0.0000669834,0.9934841,0.000733432,0.0002502974,0.004006317],"study_design_scores_gemma":[0.0001692067,0.0004862549,0.01340968,0.00003561361,0.00006463975,0.0002316667,0.0001354366,0.0006512949,0.9684848,0.0007255901,0.01559038,0.00001538617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726527,0.0103036,0.003204989,0.001427993,0.0004758173,0.00004247839,0.00131232,0.0001990146,0.01038112],"genre_scores_gemma":[0.9832379,0.00296207,0.001710217,0.0002947448,0.0000540163,0.00002641562,0.0006529609,0.0000463951,0.01101531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004425276,"threshold_uncertainty_score":0.01480407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890360853911077,"score_gpt":0.2030088833840543,"score_spread":0.1841052748449435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}