{"id":"W1984248949","doi":"10.1039/c3mb25600f","title":"Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease","year":2013,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Compute Canada","keywords":"Deferiprone; Acetylcholinesterase; Thioflavin; Disease; Chemistry; Pharmacology; Alzheimer's disease; Medicine; Biochemistry; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147526,0.0003432318,0.0001450382,0.0001402811,0.00007357379,0.0002332706,0.0001892056,0.0002039924,0.0004858224],"category_scores_gemma":[0.00008657028,0.00008018826,0.0001446058,0.00008348816,0.0001682464,0.0001894801,0.0001203581,0.0001603977,0.0001168673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000146205,"about_ca_system_score_gemma":0.000127156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005104627,"about_ca_topic_score_gemma":0.0008756228,"domain_scores_codex":[0.9999641,0.000007101996,0.000002174962,0.000008489201,0.000008801987,0.000009318434],"domain_scores_gemma":[0.9999628,0.000007554779,0.00001122711,0.000002942972,0.000005845568,0.000009656334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001514028,0.00004153297,0.0001349878,0.00007936574,0.000006825608,0.0001328539,0.00003212595,0.0006974504,0.993117,0.0004122432,0.00002455044,0.005169562],"study_design_scores_gemma":[0.00006759736,0.00216668,0.001499619,0.00001569917,0.00004971158,0.0003433169,0.00003671863,0.002054561,0.9887273,0.0001226713,0.004902382,0.00001361132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867585,0.005546487,0.004922113,0.00008812852,0.00001251237,0.00004349866,0.00006090419,0.00003851027,0.002529242],"genre_scores_gemma":[0.9934435,0.002151134,0.003629331,0.00003071893,0.000006642377,0.00001229905,0.00003914429,0.000002796106,0.0006844437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005104627,"threshold_uncertainty_score":0.00162518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04099823432556688,"score_gpt":0.280138095770606,"score_spread":0.2391398614450391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}