{"id":"W1984285081","doi":"10.1021/jm980684+","title":"Mapping the Melatonin Receptor. 6. Melatonin Agonists and Antagonists Derived from 6<i>H</i>-Isoindolo[2,1-<i>a</i>]indoles, 5,6-Dihydroindolo[2,1-<i>a</i>]isoquinolines, and 6,7-Dihydro-5<i>H</i>-benzo[<i>c</i>]azepino[2,1-<i>a</i>]indoles","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Melatonin receptor; Potency; Agonist; Melatonin; Stereochemistry; Affinities; Radioligand; Receptor; Antagonist; Radioligand Assay; Biochemistry; In vitro; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00166744,0.00119448,0.001807769,0.0002763709,0.001032299,0.0004082207,0.001361447,0.0006998109,0.0008325633],"category_scores_gemma":[0.0009276381,0.0009218802,0.0004742012,0.0009624728,0.002016718,0.0007945831,0.0003305022,0.002795979,0.00007498491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300088,"about_ca_system_score_gemma":0.0005747528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000103163,"about_ca_topic_score_gemma":0.00001040244,"domain_scores_codex":[0.9922287,0.000596652,0.002373683,0.00146126,0.001857314,0.001482329],"domain_scores_gemma":[0.9942734,0.001737488,0.001571106,0.00105229,0.000226607,0.001139127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008409614,0.0002452918,0.004893557,0.0002184575,0.0001897924,0.0008920388,0.002682382,0.00005225251,0.9679047,0.0001380266,0.003898358,0.01804413],"study_design_scores_gemma":[0.006207122,0.0002747124,0.004681475,0.001168153,0.0002540751,0.01057348,0.001031934,0.0002570002,0.8845943,0.0007839046,0.08905549,0.001118337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618864,0.02898758,0.00007695827,0.005026235,0.0008586703,0.0005265062,0.0001313852,0.0001330045,0.002373256],"genre_scores_gemma":[0.9765145,0.0159154,0.0006793021,0.003726425,0.002160075,0.00002814201,0.00002791289,0.0001577742,0.0007904648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08515713,"threshold_uncertainty_score":0.9995046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990444943290769,"score_gpt":0.230505381858595,"score_spread":0.2106009324256873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}