{"id":"W1984285081","doi":"10.1021/jm980684+","title":"Mapping the Melatonin Receptor. 6. Melatonin Agonists and Antagonists Derived from 6<i>H</i>-Isoindolo[2,1-<i>a</i>]indoles, 5,6-Dihydroindolo[2,1-<i>a</i>]isoquinolines, and 6,7-Dihydro-5<i>H</i>-benzo[<i>c</i>]azepino[2,1-<i>a</i>]indoles","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Melatonin receptor; Potency; Agonist; Melatonin; Stereochemistry; Affinities; Radioligand; Receptor; Antagonist; Radioligand Assay; Biochemistry; In vitro; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544709,0.0002044779,0.0002162725,0.0002449431,0.0002016594,0.0002655142,0.0004375521,0.0003834168,0.001635003],"category_scores_gemma":[0.0001786009,0.0001893318,0.0004115775,0.0001600063,0.000192528,0.0002080328,0.0001230209,0.0003290767,0.001304741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263782,"about_ca_system_score_gemma":0.0002815387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251083,"about_ca_topic_score_gemma":0.002235443,"domain_scores_codex":[0.9998952,0.00002279919,0.000007682969,0.00002243087,0.00002141661,0.00003043035],"domain_scores_gemma":[0.9999186,0.0000204223,0.00002116806,0.000008985141,0.00001561028,0.00001520273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003192651,0.000007885215,0.00007196965,0.00002611303,0.000001485347,0.00002639188,0.000006512947,0.00002861074,0.9989389,0.0000601874,0.00001565147,0.0007845498],"study_design_scores_gemma":[0.00004701912,0.0009445088,0.006892545,0.00001840302,0.00003064364,0.00109015,0.00006373564,0.001311601,0.9801666,0.00008575939,0.00933944,0.000009685822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581935,0.01165706,0.02313272,0.0003269666,0.00004772277,0.0002269265,0.000848958,0.00009967502,0.005466347],"genre_scores_gemma":[0.9508897,0.00692511,0.03169258,0.0001980131,0.00005137115,0.0001769134,0.002325303,0.00005470288,0.007686418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635003,"threshold_uncertainty_score":0.00546968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990444943290769,"score_gpt":0.230505381858595,"score_spread":0.2106009324256873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}