{"id":"W1984297454","doi":"10.1016/j.brainresbull.2005.06.023","title":"Chloride concentration affects Kv channel voltage-gating kinetics: Importance of experimental anion concentrations","year":2005,"lang":"en","type":"article","venue":"Brain Research Bulletin","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Heart and Stroke Foundation of Canada","keywords":"Chemistry; Gating; Osmolyte; Tetramer; Biophysics; Potassium channel; Chloride channel; Intracellular; Kinetics; Potassium; Ion channel; Chloride; Crystallography; Stereochemistry; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007014946,0.0001255628,0.0001186291,0.00005719006,0.0001614413,0.00003527055,0.0001343302,0.0001311074,0.0003541794],"category_scores_gemma":[0.0005301239,0.0001309473,0.00006492393,0.0001551238,0.0001782005,0.000008030254,0.00007329609,0.0001381515,0.00004668929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005977483,"about_ca_system_score_gemma":0.00006526692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001594051,"about_ca_topic_score_gemma":0.00001698949,"domain_scores_codex":[0.9984679,0.0001651856,0.0002686216,0.0003413133,0.0004046661,0.0003523028],"domain_scores_gemma":[0.9991941,0.00007693234,0.0001115261,0.0002424892,0.0002624269,0.0001125179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559091,0.0001408885,0.0003744477,0.00001502413,0.00001398316,0.000001005359,0.0001813188,0.0005808004,0.9498944,0.0007991301,0.04692312,0.0009199296],"study_design_scores_gemma":[0.0008004903,0.0004422611,0.0008991804,0.00002569316,0.000002058879,0.00000540162,0.0005179336,0.002055908,0.8843375,0.00002699415,0.1107551,0.0001315645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834011,0.0007586684,0.004705204,0.005596924,0.0003228833,0.0007020911,0.00001248929,0.00002949543,0.004471195],"genre_scores_gemma":[0.9958228,0.00005201082,0.0003021425,0.0003508062,0.001013839,0.00006413055,0.0002619673,0.00002142293,0.002110896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06555699,"threshold_uncertainty_score":0.5339877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242328052201586,"score_gpt":0.3272772215406109,"score_spread":0.294853941018595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}