{"id":"W1984312275","doi":"10.1002/prp2.46","title":"The in vivo efficacy and side effect pharmacology of <scp>GS</scp>‐5759, a novel bifunctional phosphodiesterase 4 inhibitor and long‐acting <i>β</i><sub>2</sub>‐adrenoceptor agonist in preclinical animal species","year":2014,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Calgary; Gilead Sciences","keywords":"Pharmacology; Phosphodiesterase; Agonist; In vivo; Medicine; Phosphodiesterase inhibitor; cGMP-specific phosphodiesterase type 5; Receptor; Chemistry; Endocrinology; Internal medicine; Biology; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887463,0.0005575678,0.0004011533,0.0002497837,0.0001333909,0.0002357862,0.0002952602,0.0004278645,0.001406584],"category_scores_gemma":[0.0001768127,0.0002005889,0.0003781466,0.0001161837,0.0003513245,0.0003568618,0.00008989673,0.001031517,0.0004350873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003530491,"about_ca_system_score_gemma":0.0003085739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139425,"about_ca_topic_score_gemma":0.00173498,"domain_scores_codex":[0.9998734,0.00001805585,0.000008301212,0.00002577386,0.00002768407,0.00004676012],"domain_scores_gemma":[0.999845,0.00002812789,0.00004107615,0.0000143302,0.00002433658,0.00004699748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001621194,0.0004615785,0.0001551355,0.00006794393,0.00001496287,0.00004664862,0.00001367219,0.0001976343,0.9935481,0.00005178123,0.0001350654,0.003686289],"study_design_scores_gemma":[0.000219632,0.01871017,0.004082205,0.00001251364,0.00008701352,0.0001864451,0.00003755193,0.00109047,0.974157,0.00003673946,0.001369924,0.00001047468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937893,0.002063241,0.001315153,0.0001941733,0.00009778455,0.00008010619,0.0007205736,0.00007505636,0.001664635],"genre_scores_gemma":[0.9888458,0.003397728,0.001257228,0.0001502418,0.0000635977,0.0001008828,0.001436422,0.00002761714,0.004720491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001406584,"threshold_uncertainty_score":0.004705489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0294952757344194,"score_gpt":0.3578183425982132,"score_spread":0.3283230668637938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}