{"id":"W1984312275","doi":"10.1002/prp2.46","title":"The in vivo efficacy and side effect pharmacology of <scp>GS</scp>‐5759, a novel bifunctional phosphodiesterase 4 inhibitor and long‐acting <i>β</i><sub>2</sub>‐adrenoceptor agonist in preclinical animal species","year":2014,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Calgary; Gilead Sciences","keywords":"Pharmacology; Phosphodiesterase; Agonist; In vivo; Medicine; Phosphodiesterase inhibitor; cGMP-specific phosphodiesterase type 5; Receptor; Chemistry; Endocrinology; Internal medicine; Biology; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002429082,0.0002698753,0.0003767757,0.0002461408,0.0003766484,0.00006094907,0.0001882586,0.0002390969,0.00002048375],"category_scores_gemma":[0.001346492,0.0002203007,0.0000805318,0.0003188716,0.001651864,0.00003160862,0.0003636763,0.0006860085,0.000003118594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001014519,"about_ca_system_score_gemma":0.0001590413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003159674,"about_ca_topic_score_gemma":0.0002676373,"domain_scores_codex":[0.9968278,0.001054922,0.0004555245,0.0007499062,0.0002896366,0.0006221483],"domain_scores_gemma":[0.9962805,0.002977166,0.0001527408,0.0001659424,0.0002499152,0.0001737623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002348009,0.0004307014,0.02234079,0.00005674197,0.0001319653,0.000007918727,0.000858664,0.00005186275,0.9698038,0.0000685182,0.002518437,0.001382625],"study_design_scores_gemma":[0.005564452,0.001710209,0.1109948,0.00003318798,0.0000366058,0.00003250369,0.001011817,0.0004167263,0.8730769,0.00002176231,0.006977604,0.0001234468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940889,0.003341865,0.00005444964,0.0007961803,0.0004969923,0.0007249869,0.00001971284,0.00001553224,0.0004613535],"genre_scores_gemma":[0.9968709,0.001798032,0.00003889101,0.0001207046,0.0007417494,0.0001476262,0.00001341432,0.00002902884,0.0002396496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09672689,"threshold_uncertainty_score":0.8983601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0294952757344194,"score_gpt":0.3578183425982132,"score_spread":0.3283230668637938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}