{"id":"W1984328121","doi":"10.1111/j.1742-7843.2009.00476.x","title":"Design, Synthesis and Pharmacological Characterization of Endomorphin Analogues with Non‐Cyclic Amino Acid Residues in Position 2","year":2009,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Vlaamse regering; Uniwersytet Łódzki; Centre National de la Recherche Scientifique","keywords":"Cyclic peptide; In vivo; Sarcosine; Chemistry; Amino acid; Stereochemistry; Peptide; Opioid peptide; In vitro; Enkephalin; Aminopeptidase; Biochemistry; Opioid; Receptor; Leucine; Glycine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707373,0.000413484,0.0003563844,0.0001665455,0.00009782962,0.0002459126,0.0003396152,0.0002380024,0.0009062911],"category_scores_gemma":[0.0002252999,0.0001922268,0.0002844927,0.0001413464,0.0001459555,0.0002013836,0.0001507905,0.0004106676,0.000274974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002286791,"about_ca_system_score_gemma":0.0002088247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000256894,"about_ca_topic_score_gemma":0.0004604106,"domain_scores_codex":[0.9999034,0.00001895717,0.00001230718,0.00002377319,0.00001978232,0.00002177063],"domain_scores_gemma":[0.9998584,0.00001603162,0.00005586041,0.0000130363,0.00002340982,0.00003321718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002123487,0.00007658504,0.00009783352,0.00006395736,0.00001015739,0.0001157962,0.00001630265,0.0003314211,0.9956506,0.00008672928,0.00002718203,0.003311021],"study_design_scores_gemma":[0.0002252233,0.005595423,0.002761736,0.00001457756,0.00005359475,0.0006566345,0.00002269959,0.0006993719,0.984143,0.00004656269,0.005761243,0.00001993093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991413,0.001903981,0.004019683,0.00005319475,0.00003557922,0.0002503568,0.0003869609,0.00003094397,0.00190637],"genre_scores_gemma":[0.9823275,0.002277746,0.01128726,0.0001303208,0.00003256935,0.0002175331,0.0009232728,0.00002007133,0.002783742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009062911,"threshold_uncertainty_score":0.00303185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0688490359276019,"score_gpt":0.3494142663924906,"score_spread":0.2805652304648887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}