{"id":"W1984329853","doi":"10.1128/jvi.80.8.3732-3742.2006","title":"Systemic Immunization with an ALVAC-HIV-1/Protein Boost Vaccine Strategy Protects Rhesus Macaques from CD4<sup>+</sup>T-Cell Loss and Reduces both Systemic and Mucosal Simian-Human Immunodeficiency Virus SHIV<sub>KU2</sub>RNA Levels","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Biology; Virology; Simian immunodeficiency virus; Immunization; AIDS Vaccines; Immunology; Human immunodeficiency virus (HIV); Simian; Virus; Immunodeficiency; Immune system; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726939,0.0005268009,0.0004402484,0.0001895579,0.0001621402,0.0002158331,0.0001846976,0.000381882,0.001253611],"category_scores_gemma":[0.0001278313,0.0001204627,0.0001918638,0.0000557994,0.0002516775,0.0001691852,0.0001278876,0.0007211211,0.0002349747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002103751,"about_ca_system_score_gemma":0.0002083586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005714379,"about_ca_topic_score_gemma":0.00126671,"domain_scores_codex":[0.9998918,0.00001641003,0.000004878511,0.00003666152,0.00001508665,0.00003507908],"domain_scores_gemma":[0.9999087,0.00001570267,0.00002108114,0.00001601601,0.00001211958,0.00002627682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003812733,0.0002624246,0.0003681005,0.00005528613,0.00001173159,0.00002400102,0.00002419242,0.00005341234,0.9946306,0.00003989352,0.00006390883,0.004085086],"study_design_scores_gemma":[0.0001891076,0.01610424,0.01053966,0.00002581911,0.0001010772,0.0005575005,0.00006172949,0.0009347696,0.9687326,0.00007209623,0.002672327,0.000009080593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973908,0.0007961251,0.001019408,0.00005650238,0.00002956711,0.00004877713,0.00007461723,0.0000724754,0.0005117389],"genre_scores_gemma":[0.9952289,0.0005694653,0.001938285,0.000079324,0.00004060354,0.00006346973,0.0002514964,0.0000172989,0.001811233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253611,"threshold_uncertainty_score":0.004193723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00976028430072778,"score_gpt":0.2338299608161954,"score_spread":0.2240696765154677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}