{"id":"W1984343582","doi":"10.1016/j.carpath.2012.06.005","title":"The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops","year":2012,"lang":"en","type":"review","venue":"Cardiovascular Pathology","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Pathogenesis; Medicine; Calcification; Aortic valve; Disease; Pathology; In vivo; Inflammation; Bioinformatics; Immunology; Cardiology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003330602,0.0005284842,0.002414339,0.00006291153,0.0001919549,0.00001988739,0.00009122463,0.0002775626,0.000003152721],"category_scores_gemma":[0.00009662325,0.0002913484,0.006075538,0.0001964471,0.000717168,0.00005828486,0.0002321781,0.0003006,0.00001940885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005776771,"about_ca_system_score_gemma":0.0001356522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004650933,"about_ca_topic_score_gemma":6.727156e-8,"domain_scores_codex":[0.9975041,0.0006244259,0.0004179808,0.0007096024,0.0002970181,0.0004469326],"domain_scores_gemma":[0.9981226,0.000190025,0.0002560838,0.0009916147,0.0001302827,0.0003093572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001497524,0.0003259429,0.00428186,0.008485026,0.007043392,0.0001037576,0.0001550692,3.180556e-7,0.000002209966,0.00008230696,0.00003594656,0.9793344],"study_design_scores_gemma":[0.004784231,0.002011714,0.07881568,0.006543669,0.2717475,0.001032613,0.0004917112,0.000008674407,0.00001816728,0.0007378974,0.6323285,0.001479714],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02063791,0.976701,0.00006946165,0.000008554844,0.0003308489,0.001833187,0.0002149918,0.00003188409,0.0001721487],"genre_scores_gemma":[0.09168257,0.9071565,0.00002849231,0.00001264834,0.0003264467,0.0003788046,0.0002951795,0.00005857491,0.00006081449],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9778547,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944950655234478,"score_gpt":0.3605816218299102,"score_spread":0.3311321152775654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}