{"id":"W1984370593","doi":"10.1371/journal.pbio.1000043","title":"The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ","year":2009,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Structural Genomics Consortium; University of Toronto","funders":"Biological and Environmental Research; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; U.S. Department of Energy","keywords":"Heme; Nuclear receptor; Repressor; Biology; Transcription factor; Ligand (biochemistry); Biochemistry; Cysteine; Histidine; Transcription (linguistics); Cell biology; Receptor; Biophysics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698576,0.0001508259,0.000157649,0.00001929093,0.000292658,0.00001233125,0.0003056662,0.0002739684,0.0000177557],"category_scores_gemma":[0.00007446145,0.00008225507,0.0001249237,0.00007520155,0.0002837726,0.00000286942,0.00003132237,0.0001912565,0.00001100168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001059577,"about_ca_system_score_gemma":0.00001703442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001381752,"about_ca_topic_score_gemma":0.000002422875,"domain_scores_codex":[0.9989327,0.00028081,0.000219523,0.0002414101,0.00006988943,0.0002556315],"domain_scores_gemma":[0.9994014,0.00003930988,0.0001129344,0.0003330347,0.00006621279,0.00004712331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002812749,0.00002925461,0.00005599009,0.000002337822,0.0001019355,3.912656e-7,0.00009378108,7.839703e-7,0.9865549,0.000748214,0.008273246,0.003857959],"study_design_scores_gemma":[0.0006367997,0.002294744,0.001131935,0.000008482012,0.00006403513,0.00001733712,0.00014147,0.00002447303,0.9690227,0.0005099398,0.02597321,0.0001749017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911658,0.005995097,0.000007280099,0.002013758,0.00009261754,0.0002386978,0.0000355858,0.0000144592,0.0004367436],"genre_scores_gemma":[0.9978492,0.001246677,0.00005040525,0.0003261055,0.0001263742,0.000007673118,0.0001401875,0.00001408037,0.000239346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01769996,"threshold_uncertainty_score":0.3354264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006512941624819425,"score_gpt":0.2336876764466679,"score_spread":0.2271747348218484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}