{"id":"W1984370593","doi":"10.1371/journal.pbio.1000043","title":"The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ","year":2009,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Structural Genomics Consortium; University of Toronto","funders":"Biological and Environmental Research; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; U.S. Department of Energy","keywords":"Heme; Nuclear receptor; Repressor; Biology; Transcription factor; Ligand (biochemistry); Biochemistry; Cysteine; Histidine; Transcription (linguistics); Cell biology; Receptor; Biophysics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005682586,0.0001659065,0.0001271119,0.00006724674,0.0001682725,0.0001653756,0.0003787,0.0002093515,0.000793006],"category_scores_gemma":[0.00009308253,0.0001376779,0.0001414973,0.00005320557,0.0002810578,0.0001465637,0.0001760356,0.0003863221,0.0003575292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004209118,"about_ca_system_score_gemma":0.000185094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100756,"about_ca_topic_score_gemma":0.0006791898,"domain_scores_codex":[0.9999478,0.000006420237,0.000003252761,0.00001410071,0.00001515292,0.00001336672],"domain_scores_gemma":[0.999965,0.000003853937,0.00001276585,0.000005217745,0.000004939948,0.000008358345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001286136,0.00002797677,0.0005994727,0.0000514237,0.000006770198,0.0002415693,0.00004450949,0.0008486485,0.9944335,0.002075859,0.0001374066,0.001404304],"study_design_scores_gemma":[0.0001079735,0.0003885684,0.0228441,0.00003339343,0.00002539583,0.001519914,0.0003744645,0.01797082,0.9369564,0.004086677,0.01565807,0.00003426471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897134,0.001923714,0.003696308,0.0006958321,0.0000557001,0.00001699645,0.0002063894,0.00009956471,0.003592082],"genre_scores_gemma":[0.9968805,0.0006697249,0.001113246,0.0001046688,0.000008449226,0.00001217323,0.0002947955,0.00001092168,0.0009055399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100756,"threshold_uncertainty_score":0.003053963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006512941624819425,"score_gpt":0.2336876764466679,"score_spread":0.2271747348218484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}