{"id":"W1984403236","doi":"10.1523/jneurosci.4132-10.2010","title":"Vesicular Sterols Are Essential for Synaptic Vesicle Cycling","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Vesicle; Synaptic vesicle; Endocytic cycle; Endocytosis; Endosome; Cell biology; Sterol; Synaptic vesicle recycling; Kiss-and-run fusion; Biology; Vesicular transport protein; Vesicle fusion; Exocytosis; Dynamin; Biophysics; Chemistry; Biochemistry; Membrane; Cholesterol; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563836,0.0005234673,0.000476634,0.0003864396,0.0004183777,0.0007424973,0.0003639273,0.000501806,0.001226145],"category_scores_gemma":[0.0004027767,0.0002507422,0.0002128776,0.0002101506,0.000352817,0.0003472773,0.0005071525,0.0003133531,0.001265497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005158347,"about_ca_system_score_gemma":0.0003813201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009317283,"about_ca_topic_score_gemma":0.0009155305,"domain_scores_codex":[0.9997951,0.00002770686,0.00003061288,0.00003957553,0.0000712972,0.00003570261],"domain_scores_gemma":[0.9997446,0.00004318002,0.00006162783,0.00003580111,0.0000534379,0.00006135819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001273782,0.000009664533,0.0004099359,0.00009340866,0.000007345891,0.0002074189,0.00001506904,0.0000754404,0.9954527,0.0003812522,0.00005761968,0.003162839],"study_design_scores_gemma":[0.00001842651,0.00007112542,0.006782924,0.00001474305,0.00002709118,0.0009289344,0.00004558369,0.0008134549,0.9851574,0.0005670015,0.005558261,0.00001508803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695089,0.0146509,0.01031025,0.000307948,0.0001360385,0.00005319836,0.0009112604,0.0008831372,0.003238396],"genre_scores_gemma":[0.9923669,0.002519633,0.002545201,0.00002624634,0.00001398628,0.00001574612,0.0004698428,0.00006122007,0.001981315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226145,"threshold_uncertainty_score":0.004101932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153092677360724,"score_gpt":0.2522484882785702,"score_spread":0.2407175615049629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}