{"id":"W1984403236","doi":"10.1523/jneurosci.4132-10.2010","title":"Vesicular Sterols Are Essential for Synaptic Vesicle Cycling","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Vesicle; Synaptic vesicle; Endocytic cycle; Endocytosis; Endosome; Cell biology; Sterol; Synaptic vesicle recycling; Kiss-and-run fusion; Biology; Vesicular transport protein; Vesicle fusion; Exocytosis; Dynamin; Biophysics; Chemistry; Biochemistry; Membrane; Cholesterol; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002609447,0.00006607625,0.00009296635,0.00003406215,0.00007662999,0.00003419555,0.0002820014,0.00005627331,0.000002458804],"category_scores_gemma":[0.0001740277,0.00005709791,0.0001142724,0.00005373867,0.0000739774,0.00001091479,0.00002278623,0.0001179981,5.261123e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002170269,"about_ca_system_score_gemma":0.00004218628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.341868e-7,"about_ca_topic_score_gemma":0.000003612897,"domain_scores_codex":[0.9993632,0.00001351398,0.0002003291,0.0001420459,0.0001445004,0.0001363971],"domain_scores_gemma":[0.9994503,0.000007868325,0.0001963715,0.0001727721,0.0000978518,0.00007486783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004768428,0.00003314334,0.001601079,0.000007122276,0.000003158251,0.00001407244,0.00001094485,0.0000701993,0.9980276,0.00001764979,0.00002648398,0.0001408763],"study_design_scores_gemma":[0.0005970559,0.0005079553,0.03011825,0.00001496409,0.00003032506,0.000212021,0.00002321573,0.0007673178,0.9496164,0.0001275542,0.01786125,0.0001236983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542555,0.00006149291,0.04446249,0.0001939099,0.0009418533,0.00006639215,0.000002724026,0.000002202409,0.0000134599],"genre_scores_gemma":[0.998552,0.00002723796,0.0008008991,0.0001964231,0.0003724272,0.000001292185,0.000005902045,0.000008048662,0.00003575303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04841119,"threshold_uncertainty_score":0.2328385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153092677360724,"score_gpt":0.2522484882785702,"score_spread":0.2407175615049629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}