{"id":"W1984427209","doi":"10.1210/en.2013-1713","title":"Regulation of Hepatic Glucose Production by Gq-Coupled Receptors: Potential New Targets for Treatment of Type 2 Diabetes","year":2013,"lang":"en","type":"letter","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Heterotrimeric G protein; Receptor; Biology; G protein; Gq alpha subunit; Cell biology; Adenylyl cyclase; Phospholipase C; Signal transduction; Intracellular; Rhodopsin-like receptors; Diacylglycerol kinase; HEK 293 cells; Biochemistry; Protein kinase C; Agonist; Metabotropic receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003474233,0.0004514711,0.000741625,0.0005964288,0.000121122,0.0005907738,0.0005733302,0.0006378015,0.004455929],"category_scores_gemma":[0.0001962805,0.0001133545,0.0005138122,0.0004391467,0.0002549405,0.0005568909,0.0003365672,0.001629961,0.001093412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002745737,"about_ca_system_score_gemma":0.000210652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002977636,"about_ca_topic_score_gemma":0.000790983,"domain_scores_codex":[0.9999195,0.00001836227,0.000006307913,0.00001395387,0.00002189897,0.00001984351],"domain_scores_gemma":[0.9999177,0.00001511742,0.00002289016,0.000005288302,0.00001880896,0.00002013806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00301078,0.001667105,0.001025214,0.004010177,0.000255848,0.0006527778,0.00009662185,0.0008036747,0.07217087,0.006104209,0.02602207,0.8841806],"study_design_scores_gemma":[0.003462044,0.007461167,0.01292135,0.002344522,0.0009018835,0.002373722,0.0002553917,0.003030693,0.03886988,0.009468505,0.9187819,0.0001289376],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"editorial","genre_scores_codex":[0.04207494,0.9281875,0.01001638,0.007923754,0.002115646,0.0001450077,0.0005836698,0.000372317,0.008580675],"genre_scores_gemma":[0.1299408,0.8407697,0.01082296,0.00541845,0.002518493,0.0002481247,0.0008558487,0.00008002567,0.009345559],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.004455929,"threshold_uncertainty_score":0.01490653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011245336600126,"score_gpt":0.2275197250607027,"score_spread":0.2174072716947015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}