{"id":"W1984433766","doi":"10.1182/blood-2012-02-412080","title":"Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia","funders":"Canadian Institutes of Health Research; CSL Behring; Canadian Blood Services; Heart and Stroke Foundation of British Columbia and Yukon; University of British Columbia; Heart and Stroke Foundation of Canada","keywords":"Thrombin; Complement component 5; Complement system; Complement membrane attack complex; Anaphylatoxin; C3-convertase; Biochemistry; Proteolysis; Cell biology; Chemistry; Coagulation; Fibrin; Complement control protein; Alternative complement pathway; Biology; Immunology; Enzyme; Platelet; Immune system; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005303264,0.0001710505,0.000228102,0.00005678121,0.0001849714,0.00004695295,0.0001139516,0.0000625604,0.0005120895],"category_scores_gemma":[0.00004512594,0.0001153586,0.00006581223,0.000170616,0.00004361243,0.0001919071,0.00006224955,0.0001379378,0.0001103563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000259391,"about_ca_system_score_gemma":0.00009756443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001671553,"about_ca_topic_score_gemma":0.000005416485,"domain_scores_codex":[0.9986622,0.0000903622,0.0002485882,0.000232974,0.0003962699,0.0003695658],"domain_scores_gemma":[0.9991379,0.00003067674,0.0001415346,0.0004591436,0.0001071055,0.0001236332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004748152,0.003328809,0.02658933,0.0001998157,0.0004063565,0.00001311343,0.002758935,9.611168e-7,0.945224,0.01218959,0.00550824,0.003733372],"study_design_scores_gemma":[0.001776082,0.0002127699,0.07209396,0.00005362004,0.0003098878,0.0001692388,0.0002641451,0.000009183783,0.9179918,0.0001784138,0.006797563,0.0001433992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994351,0.0001798059,0.0001507082,0.002047143,0.000391138,0.0009674449,0.000005405841,0.00009909532,0.001808268],"genre_scores_gemma":[0.9964657,0.00002449399,0.0006788974,0.0008111506,0.000510533,0.0000736462,0.0001514058,0.00002767509,0.001256504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04550462,"threshold_uncertainty_score":0.5607021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06973897967794182,"score_gpt":0.2903356110889563,"score_spread":0.2205966314110145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}