{"id":"W1984433766","doi":"10.1182/blood-2012-02-412080","title":"Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia","funders":"Canadian Institutes of Health Research; CSL Behring; Canadian Blood Services; Heart and Stroke Foundation of British Columbia and Yukon; University of British Columbia; Heart and Stroke Foundation of Canada","keywords":"Thrombin; Complement component 5; Complement system; Complement membrane attack complex; Anaphylatoxin; C3-convertase; Biochemistry; Proteolysis; Cell biology; Chemistry; Coagulation; Fibrin; Complement control protein; Alternative complement pathway; Biology; Immunology; Enzyme; Platelet; Immune system; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004779821,0.000333267,0.0002578589,0.0002567681,0.0002120604,0.0006930266,0.0003213361,0.0004981034,0.001151974],"category_scores_gemma":[0.0005047654,0.0001074849,0.0003354451,0.0001641128,0.0002950038,0.000404057,0.0003141764,0.0005941214,0.0003301921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005014918,"about_ca_system_score_gemma":0.0004162107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075589,"about_ca_topic_score_gemma":0.0006542027,"domain_scores_codex":[0.9997143,0.00007119204,0.00002319063,0.00004204554,0.00008911897,0.00006007888],"domain_scores_gemma":[0.9997792,0.00006355516,0.00004931879,0.00002833304,0.00003821039,0.00004133964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002985075,0.00002627784,0.000645256,0.00007640593,0.00001420149,0.0002733119,0.00003971228,0.0001126743,0.9937512,0.001139277,0.00005876191,0.003564396],"study_design_scores_gemma":[0.00002561109,0.0004904146,0.004905459,0.00001748041,0.00003347067,0.0006854828,0.00003580124,0.001693048,0.9890814,0.000559976,0.002462924,0.000008945166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546804,0.01233394,0.0268176,0.000321156,0.00008733961,0.0001406992,0.000298537,0.0001363812,0.005183925],"genre_scores_gemma":[0.9926172,0.001057028,0.005140915,0.00006988483,0.00001831396,0.00002025069,0.0002085459,0.000006015226,0.0008618049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151974,"threshold_uncertainty_score":0.003853738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06973897967794182,"score_gpt":0.2903356110889563,"score_spread":0.2205966314110145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}