{"id":"W1984449141","doi":"10.1021/ja806462x","title":"Biomimetic Cleavage of RNA Models Promoted by a Dinuclear Zn(II) Complex in Ethanol. Greater than 30 kcal/mol Stabilization of the Transition State for Cleavage of a Phosphate Diester","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Cleavage (geology); Medicinal chemistry; Dissociation (chemistry); Kinetics; Trifluoromethanesulfonate; Phosphate; Dissociation constant; Aryl; Stereochemistry; Ethanol; Reaction rate constant; Catalysis; Crystallography; Physical chemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867658,0.0001504109,0.0003883482,0.00001112076,0.00004959559,0.000003226294,0.0003637791,0.0000973506,0.000004318801],"category_scores_gemma":[0.00003518708,0.00009681657,0.0005009152,0.0001881612,0.0008507843,0.00001166166,0.0001135878,0.0001617252,5.176323e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004259726,"about_ca_system_score_gemma":0.00005945787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002330501,"about_ca_topic_score_gemma":5.143427e-7,"domain_scores_codex":[0.9988185,0.00006048995,0.0005280824,0.0001617557,0.0002428371,0.0001883002],"domain_scores_gemma":[0.9986599,0.00002312917,0.0008566699,0.0002566428,0.0001541269,0.00004954063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004127939,0.0002073656,0.0005112981,0.00008805595,0.0001128181,2.495672e-7,0.001266272,0.00009971755,0.9947479,5.200377e-7,0.002255326,0.0002976401],"study_design_scores_gemma":[0.001045521,0.0003045065,0.0008174292,0.00007183295,0.00005507651,0.00001193303,0.0003187554,0.000981009,0.9961186,0.00009336652,0.00007750135,0.0001044761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975554,0.00007966354,0.001645679,0.0003616812,0.00002264942,0.0001982361,0.0001022388,0.000002302768,0.00003213465],"genre_scores_gemma":[0.998795,0.0001715804,0.0007626513,0.0001784323,0.00002706248,0.000003764816,0.00001084393,0.00002414381,0.00002646208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177824,"threshold_uncertainty_score":0.3948065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472202515351921,"score_gpt":0.2309966158961842,"score_spread":0.216274590742665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}