{"id":"W1984463125","doi":"10.1016/j.biomaterials.2010.10.025","title":"Multivalent niacin nanoconjugates for delivery to cytoplasmic lipid droplets","year":2010,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nanocarriers; BODIPY; Niacin; Organelle; Lipid droplet; Biophysics; Fluorescence microscope; PEGylation; Conjugate; Polyethylene glycol; Click chemistry; Drug delivery; Materials science; Chemistry; Nanotechnology; Fluorescence; Biochemistry; Combinatorial chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751259,0.0001832892,0.0001847932,0.00005497422,0.00007623665,0.00006385788,0.0002379731,0.000179447,0.0001169961],"category_scores_gemma":[0.00009719097,0.0001623207,0.0001017272,0.00003599524,0.00003980251,0.000004946939,0.0001189298,0.00001041824,0.0001568365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006312961,"about_ca_system_score_gemma":0.00004368231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002690166,"about_ca_topic_score_gemma":0.00006440122,"domain_scores_codex":[0.9989722,0.00002500334,0.0002527317,0.000385828,0.00007140271,0.0002928401],"domain_scores_gemma":[0.9993443,0.00001410138,0.00006517664,0.0003463578,0.0001156833,0.0001143168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002713714,0.00003994343,0.0002544204,0.00001863185,0.00003205082,0.00000123662,0.00003265744,0.000001729278,0.988455,0.00001341821,0.00951704,0.001362513],"study_design_scores_gemma":[0.0004007671,0.000373269,0.0005217242,0.00001275094,0.00001146031,0.00001091589,0.00001788191,0.000008027952,0.8980568,0.00002203735,0.1003521,0.000212323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966673,0.00003937194,0.0003901887,0.0001899037,0.00186957,0.0004996073,0.0002281571,0.00002691742,0.00008904279],"genre_scores_gemma":[0.9956713,0.00003175775,0.001933983,0.0004273683,0.0007476725,0.000167423,0.0001737227,0.00002736092,0.0008194094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09083501,"threshold_uncertainty_score":0.6619246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039541286189192,"score_gpt":0.2662884114400136,"score_spread":0.2558929985781217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}