{"id":"W1984463125","doi":"10.1016/j.biomaterials.2010.10.025","title":"Multivalent niacin nanoconjugates for delivery to cytoplasmic lipid droplets","year":2010,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nanocarriers; BODIPY; Niacin; Organelle; Lipid droplet; Biophysics; Fluorescence microscope; PEGylation; Conjugate; Polyethylene glycol; Click chemistry; Drug delivery; Materials science; Chemistry; Nanotechnology; Fluorescence; Biochemistry; Combinatorial chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002480867,0.0003735979,0.0002586586,0.0001955977,0.0002568391,0.0003940582,0.000229529,0.0003169514,0.0006494583],"category_scores_gemma":[0.0001572465,0.0001536037,0.0001465439,0.0001839101,0.000277672,0.000335431,0.0003863751,0.0003789246,0.0002899266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007366844,"about_ca_system_score_gemma":0.0003794088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083724,"about_ca_topic_score_gemma":0.00188892,"domain_scores_codex":[0.9998546,0.00002360137,0.00001244474,0.00003146007,0.00004418513,0.00003374398],"domain_scores_gemma":[0.9999425,0.0000113132,0.00001655282,0.000007221899,0.00001180939,0.00001057814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004414135,0.000005224894,0.00002434418,0.00003485646,0.000002214871,0.00001713711,0.00001313168,0.00007045464,0.9981105,0.0002591307,0.00002448955,0.001394265],"study_design_scores_gemma":[0.000002989754,0.00002477037,0.00007716805,0.000001668858,0.000003563416,0.00002838502,0.000005054647,0.0003040815,0.9984556,0.00002409787,0.001070488,0.000002093546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579785,0.005329233,0.03134163,0.0002605658,0.00007395725,0.0001060218,0.0001579566,0.0002806663,0.00447133],"genre_scores_gemma":[0.9800954,0.001657821,0.01291608,0.00006419963,0.000006768012,0.00007753946,0.00009953624,0.00004777778,0.005034906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083724,"threshold_uncertainty_score":0.005345047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039541286189192,"score_gpt":0.2662884114400136,"score_spread":0.2558929985781217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}