{"id":"W1984509557","doi":"10.1021/cb5003416","title":"Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Aminoglycoside; Cytotoxicity; Antibacterial activity; RNA; Neomycin; Chemistry; Enzyme; Stereochemistry; Antibiotics; Biochemistry; Pharmacology; Biology; Bacteria; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571719,0.000180084,0.0002872839,0.00003290127,0.00004876931,0.00001001569,0.0001867043,0.0004115286,0.0000401016],"category_scores_gemma":[0.0002616401,0.0001544729,0.00005661263,0.00007267464,0.000173169,0.000004555602,0.0001231778,0.00008379589,0.000001881592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007366259,"about_ca_system_score_gemma":0.00002021118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001268176,"about_ca_topic_score_gemma":0.00002420274,"domain_scores_codex":[0.9988105,0.0001373508,0.0002888262,0.0004492066,0.00007116221,0.0002429168],"domain_scores_gemma":[0.9993004,0.00004432462,0.000149463,0.0003640227,0.00006252325,0.0000792465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002010937,0.00001704125,0.001550722,0.00002048076,0.00002347329,2.473348e-7,0.00001705305,0.000002504165,0.9958509,0.0009598797,0.0001871269,0.001169513],"study_design_scores_gemma":[0.0004329795,0.0001454851,0.001873067,0.00001206602,0.00001278632,0.000005246973,0.000002677933,0.00001441328,0.9840409,0.005049614,0.008234544,0.0001762859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958749,0.0003010417,0.003142447,0.0002575763,0.0001180431,0.0001265033,0.00006644582,0.00001178622,0.0001012099],"genre_scores_gemma":[0.9972184,0.00009327744,0.001816544,0.0002094098,0.0003354196,0.000003712535,0.000243657,0.00001502634,0.00006452332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01181003,"threshold_uncertainty_score":0.629922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005261878315774875,"score_gpt":0.2159145859058617,"score_spread":0.2106527075900868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}