{"id":"W1984509557","doi":"10.1021/cb5003416","title":"Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Aminoglycoside; Cytotoxicity; Antibacterial activity; RNA; Neomycin; Chemistry; Enzyme; Stereochemistry; Antibiotics; Biochemistry; Pharmacology; Biology; Bacteria; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007105862,0.0001335954,0.0001268604,0.0000564787,0.00007942571,0.000148499,0.0001475972,0.0001443423,0.0005088909],"category_scores_gemma":[0.00009566509,0.00006542588,0.00008648035,0.00005217579,0.0001443075,0.0001249615,0.0000882525,0.0002478179,0.0001320751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001963075,"about_ca_system_score_gemma":0.0001038095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004991569,"about_ca_topic_score_gemma":0.0006250136,"domain_scores_codex":[0.9999536,0.00001080778,0.000004474779,0.00000779925,0.0000133041,0.000009917757],"domain_scores_gemma":[0.9999523,0.00000967801,0.0000157034,0.000005641257,0.000007502616,0.000009139356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006826377,0.00001912312,0.0000987562,0.00001704301,0.000002254739,0.00002567441,0.00001095119,0.0002235412,0.998446,0.0001297633,0.0000184794,0.0009400123],"study_design_scores_gemma":[0.000008333823,0.0002662789,0.0009027495,0.000001932319,0.000003690086,0.00005754222,0.000009337044,0.0006655554,0.9974496,0.00002345131,0.0006093432,0.000002257176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972872,0.0004394181,0.001175078,0.00003130979,0.000005935469,0.000007851394,0.00004299901,0.00002314273,0.0009871151],"genre_scores_gemma":[0.9978047,0.0003462429,0.0009414623,0.00002368748,0.000001709361,0.000006800436,0.00005688768,0.000007642611,0.0008109564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005088909,"threshold_uncertainty_score":0.001702428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005261878315774875,"score_gpt":0.2159145859058617,"score_spread":0.2106527075900868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}