{"id":"W1984573095","doi":"10.1186/ar2273","title":"Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy","year":2007,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; McGill University; Institut national de psychiatrie légale Philippe-Pinel; Shriners Hospitals for Children - Canada; Montreal Children's Hospital","funders":"National Institutes of Health; Shriners Hospitals for Children","keywords":"Collagenase; Proinflammatory cytokine; Chondrocyte; Prostaglandin E2; Cartilage; Gene expression; Osteoarthritis; Cell biology; Cleavage (geology); Internal medicine; Rheumatology; Medicine; Articular cartilage; Prostaglandin; Chemistry; Endocrinology; Anatomy; Gene; Pathology; Biology; Inflammation; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002393461,0.0003478601,0.0003449411,0.0002272073,0.0001053967,0.0003490116,0.00009585466,0.0002502557,0.001004483],"category_scores_gemma":[0.0002805336,0.0001241992,0.0001723085,0.0001416516,0.0003049992,0.0001562207,0.0001569277,0.0003928828,0.0003771242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000164292,"about_ca_system_score_gemma":0.0002435691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004260537,"about_ca_topic_score_gemma":0.0007118237,"domain_scores_codex":[0.9997907,0.00006459295,0.00002661636,0.0000257267,0.00005962,0.00003274298],"domain_scores_gemma":[0.999774,0.00007989126,0.00003616516,0.00002831825,0.00002831142,0.00005329991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003006954,0.00003357868,0.0002038164,0.00004117521,0.000003583693,0.00004635709,0.00001129983,0.00002139267,0.9984918,0.00001075097,0.00001468033,0.0008208345],"study_design_scores_gemma":[0.00005870339,0.001695629,0.006253296,0.00000744618,0.00001526986,0.0003009332,0.00005488367,0.0002098798,0.990288,0.00002506702,0.001086862,0.000004145229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932903,0.004066707,0.001184172,0.00009462362,0.00005182341,0.00003233342,0.0002309673,0.00003341714,0.001015643],"genre_scores_gemma":[0.9937019,0.001525531,0.001742186,0.00007667872,0.00003692858,0.00004601344,0.0004165284,0.00001052804,0.002443698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004483,"threshold_uncertainty_score":0.003360331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888414941945445,"score_gpt":0.3094036166719277,"score_spread":0.2805194672524733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}