{"id":"W1984573095","doi":"10.1186/ar2273","title":"Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy","year":2007,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; McGill University; Institut national de psychiatrie légale Philippe-Pinel; Shriners Hospitals for Children - Canada; Montreal Children's Hospital","funders":"National Institutes of Health; Shriners Hospitals for Children","keywords":"Collagenase; Proinflammatory cytokine; Chondrocyte; Prostaglandin E2; Cartilage; Gene expression; Osteoarthritis; Cell biology; Cleavage (geology); Internal medicine; Rheumatology; Medicine; Articular cartilage; Prostaglandin; Chemistry; Endocrinology; Anatomy; Gene; Pathology; Biology; Inflammation; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001011663,0.0003600811,0.0007191412,0.0006728582,0.0003544365,0.0001065818,0.0001627195,0.0002461628,0.0001399261],"category_scores_gemma":[0.0003791948,0.0003312916,0.0001102233,0.0008931889,0.0003840624,0.0002663842,0.0001447487,0.0002457575,0.00001557155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096586,"about_ca_system_score_gemma":0.000425422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000159837,"about_ca_topic_score_gemma":0.007855606,"domain_scores_codex":[0.9961972,0.0004501087,0.0007025943,0.0007122802,0.0009149934,0.001022835],"domain_scores_gemma":[0.9979972,0.0003037915,0.0001066978,0.0005382583,0.0003305459,0.0007234842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003117326,0.0006573124,0.02052889,0.0001113999,0.00001825408,0.002237724,0.003965908,0.000002513365,0.9641821,0.00005701227,0.0004185261,0.004703055],"study_design_scores_gemma":[0.01600846,0.003941958,0.0070904,0.00152612,0.00001146642,0.0001108195,0.001348095,0.000006050667,0.9659863,0.00007012936,0.003599615,0.0003005614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728125,0.0214674,0.000005955205,0.0002451515,0.00006053459,0.005078754,0.00009612826,0.00005573698,0.0001778372],"genre_scores_gemma":[0.991621,0.005703813,0.0009280686,0.0001740239,0.00010668,0.0007576636,0.000166104,0.0000654535,0.0004772479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01880844,"threshold_uncertainty_score":0.9999139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888414941945445,"score_gpt":0.3094036166719277,"score_spread":0.2805194672524733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}