{"id":"W1984589010","doi":"10.1016/j.stem.2014.02.005","title":"Multifaceted Regulation of Somatic Cell Reprogramming by mRNA Translational Control","year":2014,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal General Hospital; McGill University Health Centre; University of Ottawa; Children's Hospital of Eastern Ontario; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Biology; SOX2; Induced pluripotent stem cell; Embryonic stem cell; Somatic cell; Cell biology; Translation (biology); KLF4; Translational regulation; Post-translational regulation; Stem cell; Messenger RNA; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005629779,0.000215869,0.0002707017,0.00006388129,0.0000900906,0.00002745136,0.0002767498,0.0002284726,0.00006192982],"category_scores_gemma":[0.00001107164,0.0002170958,0.0001580663,0.0001197059,0.00008102742,0.000007741198,0.00004666033,0.000121066,0.00005773933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000176859,"about_ca_system_score_gemma":0.00005283464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001879657,"about_ca_topic_score_gemma":0.000003401115,"domain_scores_codex":[0.9980035,0.0002621308,0.000469408,0.0004997672,0.0003851547,0.0003800244],"domain_scores_gemma":[0.9988536,0.00007611104,0.0002476809,0.0005370887,0.0001472527,0.0001382527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007696853,0.0001944748,0.002018178,0.0002922554,0.00001580824,5.111741e-7,0.00006503359,0.0009110317,0.9920088,0.000003804871,0.0009481269,0.003464975],"study_design_scores_gemma":[0.002396805,0.0002270529,0.0007662936,0.00001714156,0.00003007125,0.00000151139,0.00005306213,0.01179651,0.9679819,0.00001831695,0.01648461,0.0002267244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548335,0.001605863,0.02969853,0.00006915702,0.0001102385,0.0007026665,0.00004409785,0.00002903462,0.01290688],"genre_scores_gemma":[0.9905441,0.00004430911,0.001203277,0.00003142703,0.00007779766,0.00002797333,0.0002873552,0.00004181333,0.007741973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03571054,"threshold_uncertainty_score":0.8852908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00684016378068968,"score_gpt":0.2183980797376638,"score_spread":0.2115579159569741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}