{"id":"W1984608525","doi":"10.1016/j.cellsig.2011.06.012","title":"Phospholipase C-η2 is activated by elevated intracellular Ca2+ levels","year":2011,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Biotechnology and Biological Sciences Research Council; University of St Andrews; Natural Environment Research Council; Sight Research UK","keywords":"Phospholipase C; Monensin; Intracellular; Enzyme activator; Chemistry; Biochemistry; Cell biology; Antiporter; Mutant; Phospholipase; C2 domain; Enzyme; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003419924,0.0003467747,0.0002518429,0.00007563394,0.0001959724,0.00004461145,0.0003131766,0.0003406372,0.001143926],"category_scores_gemma":[0.00004696376,0.0003633092,0.0001757765,0.0002258133,0.00009720513,0.00001354775,0.00009868912,0.0002212329,0.00009086527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002940756,"about_ca_system_score_gemma":0.00008785542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006092021,"about_ca_topic_score_gemma":0.000001562247,"domain_scores_codex":[0.9980701,0.0001016815,0.0004185521,0.0006440991,0.0002566103,0.0005089545],"domain_scores_gemma":[0.9989322,0.000009783344,0.0001940689,0.0004629752,0.0001621065,0.0002388569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001018978,0.0001111335,0.00007896339,0.00002379197,0.00009554873,0.00003202201,0.0002163014,0.00003452626,0.9971261,0.00008497254,0.001075949,0.001018794],"study_design_scores_gemma":[0.000675498,0.0001201125,0.00001676078,0.00004068822,0.00003964535,0.000008091941,0.00006225277,0.0007409084,0.9803979,0.0002027415,0.01722544,0.0004699273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.89821,0.003913344,0.09643313,0.0000433834,0.0001335199,0.0003508669,0.00005039657,0.00007779351,0.000787493],"genre_scores_gemma":[0.9955087,0.00005840772,0.001988471,0.0004118535,0.0001696831,0.00002810202,0.0003697244,0.00007642085,0.001388655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09729861,"threshold_uncertainty_score":0.9998819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468695173872715,"score_gpt":0.225236057927428,"score_spread":0.2005491061887008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}