{"id":"W1984654825","doi":"10.1016/j.bbrep.2015.03.004","title":"Influence of chemical denaturants on the activity, fold and zinc status of anthrax lethal factor","year":2015,"lang":"en","type":"article","venue":"Biochemistry and Biophysics Reports","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Chemistry; Guanidine; Urea; Zinc; Biophysics; Ionic strength; Anthrax toxin; Native state; Crystallography; Biochemistry; Aqueous solution; Biology; Recombinant DNA; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757511,0.0002632928,0.0001876381,0.00007704156,0.00008594737,0.0002037032,0.0001825449,0.0001703509,0.0005248604],"category_scores_gemma":[0.000388112,0.00008407441,0.0001105808,0.00008329364,0.0001831302,0.0001522009,0.0001259282,0.0003606244,0.0001321516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733031,"about_ca_system_score_gemma":0.0001465109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008364521,"about_ca_topic_score_gemma":0.0009761243,"domain_scores_codex":[0.9998597,0.00003314217,0.00001895214,0.00002714112,0.00003445392,0.00002656638],"domain_scores_gemma":[0.9998145,0.00005417508,0.00005309821,0.00001702624,0.00003317343,0.00002811907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001589257,0.00002890212,0.0002336331,0.00003826277,0.000006282447,0.00002351497,0.00001860691,0.0000653492,0.9986369,0.00002608446,0.0000137793,0.0007496168],"study_design_scores_gemma":[0.000005688486,0.0002978003,0.001790183,0.000003247674,0.000008382843,0.00003911614,0.00001438516,0.0002735131,0.9970023,0.00001037103,0.0005514708,0.000003512946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997748,0.0009332247,0.0006519069,0.00004469401,0.00001692005,0.00001018919,0.0001101901,0.00001707958,0.0004679115],"genre_scores_gemma":[0.9976662,0.0005324109,0.0009114949,0.00002960835,0.000008060993,0.0000103193,0.0001963003,0.00001010829,0.0006353922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008364521,"threshold_uncertainty_score":0.001755774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02147571949369593,"score_gpt":0.2755562969493925,"score_spread":0.2540805774556966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}